Results 1 to 10 of about 50,651 (209)

Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization

open access: yesAsian Journal of Pharmaceutical Sciences, 2015
The objective of the present study was to alter the crystal habit of itraconazole (ITZ) by cooling and anti-solvent crystallization and characterize its properties.
Pornsak Sriamornsak   +1 more
doaj   +1 more source

ENHANCED DISSOLUTION RATE OF IBUPROFEN USING SURFACTANTS AND WATER SOLUBLE CARRIERS [PDF]

open access: yesBulletin of Pharmaceutical Sciences. Assiut University, 1984
The influence of some non-ionic surfactants as well as polyethylene glycol 6000 and dextrose as water soluble carrier, on the dissolution of poorly soluble drug, ibuprofen, was studied.
A. Abd El-Gawad, A. Nouh, M. El-Shaboury
doaj   +1 more source

Preparation and Characterization of PEG4000 Palmitate/PEG8000 Palmitate-Solid Dispersion Containing the Poorly Water-Soluble Drug Andrographolide

open access: yesAdvances in Polymer Technology, 2020
Solid dispersion (SD) is the effective approach to improve the dissolution rate and bioavailability of class II drugs with low water solubility and high tissue permeability in the Biopharmaceutics Classification System.
Qingyun Zeng   +6 more
doaj   +1 more source

Investigation of Crystallization and Salt Formation of Poorly Water-Soluble Telmisartan for Enhanced Solubility

open access: yesPharmaceutics, 2019
The crystal changes and salt formation of poorly water-soluble telmisartan (TEL) in various solvents were investigated for enhanced solubility, stability and crystallinity. Polymorphic behaviors of TEL were characterized by dispersing in distilled water,
Chulhun Park   +9 more
doaj   +1 more source

Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

open access: yesAsian Journal of Pharmaceutical Sciences
While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce
Jung Suk Kim   +12 more
doaj   +1 more source

Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2016
The formulation development for poorly soluble drugs still remains a challenge. Supersaturating drug delivery systems (SDDS) or drug delivery systems based on supersaturating provide a promising way to improve the oral bioavailability of poorly water ...
Meiyan Yang   +5 more
doaj   +1 more source

Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin

open access: yesAsian Journal of Pharmaceutical Sciences, 2014
We applied a combination of inorganic mesoporous silica material, frequently used as drug carriers, and a natural organic polymer alginate (ALG), to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin (IND ...
Liang Hu   +7 more
doaj   +1 more source

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