Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles [PDF]
Acta Pharmaceutica Sinica B, 2019 Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash
Jinsong Tao, Shing Fung Chow, Ying Zheng
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Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing [PDF]
Pharmaceutics, 2020 Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process.
Hui-Won Cho +3 more
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Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique [PDF]
Advanced Pharmaceutical Bulletin, 2011 Introduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by ...
Parvin Zakeri-Milani +5 more
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Preclinical Bioavailability Assessment of a Poorly Water-Soluble Drug, HGR4113, Using a Stable Isotope Tracer [PDF]
Pharmaceutics, 2023 Drug solubility limits intravenous dosing for poorly water-soluble medicines, which misrepresents their bioavailability estimation. The current study explored a method using a stable isotope tracer to assess the bioavailability of drugs that are poorly ...
Eun Ji Ha +5 more
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Surfactant Mediated Accelerated and Discriminatory In Vitro Drug Release Method for PLGA Nanoparticles of Poorly Water-Soluble Drug [PDF]
Pharmaceuticals, 2022 In vitro drug release testing is an important quality control tool for formulation development. However, the literature has evidence that poly-lactide-co-glycolide (PLGA)-based formulations show a slower in vitro drug release than a real in vivo drug ...
Ritu Gupta +3 more
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Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability [PDF]
Molecules, 2015 The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery ...
Marko Krstić +3 more
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Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug [PDF]
Scientia Pharmaceutica, 2016 The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent.
Suporn Charumanee +4 more
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Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug [PDF]
Asian Journal of Pharmaceutical Sciences, 2019 The purpose of the present study was to investigate the interaction of Cinnarizine (CIN) with Hydroxypropyl-β-Cyclodextrin (HPβCD) in the presence of Hydroxy Acids (HA).
Mayank Patel, Rajashree Hirlekar
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Pharmaceutics, 2019 Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water ...
Thao T. D. Tran, Phuong H. L. Tran
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Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug. [PDF]
Polymers (Basel), 2022 Liu Y, Chen X, Liu Y, Gao Y, Liu P.
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