Molecules, 2016 The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative ...
Kyeong-Ok Choi +3 more
doaj +1 more source
Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin [PDF]
, 2019 Topical treatment of wound infections is often a challenge due to limited drug availability at the site of infection. Topical drug delivery is an attractive option for reducing systemic side effects, provided that a more selective and sustained local ...
Bayer, Ilker S. +6 more
core +2 more sources
Anticancer activity of rutin and its combination with ionic liquids on renal cells [PDF]
, 2020 The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC.
Araújo, Maria Eduarda Machado +6 more
core +1 more source
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Vorinostat is a histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) with anticancer properties. However, it is plagued by low water solubility, low permeability (BCS class IV drug), and suboptimal pharmacokinetics. The purpose
Ashok Kumar Janakiraman +4 more
doaj +1 more source
Controlled release from zein matrices: Interplay of drug hydrophobicity and pH [PDF]
, 2015 Purpose: In earlier studies, the corn protein zein is found to be suitable as a sustained release agent, yet the range of drugs for which zein has been studied remains small.
A Katchalsky +34 more
core +2 more sources
Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
Journal of Pharmacy and Bioallied Sciences, 2012 The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process.
Divyesh Thakar +2 more
doaj +1 more source
In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs
European Journal of Pharmaceutical Sciences, 2000 Although several routes of administration can be considered for new drug entities, the most popular remains the oral route. To predict the in vivo performance of a drug after oral administration from in vivo data, it is essential that the limiting factor to absorption can be modelled in vitro.
Dressman, J.B., Reppas, C.
openaire +3 more sources
Facile one-pot synthesis of amoxicillin-coated gold nanoparticles and their antimicrobial activity [PDF]
, 2014 Nanomaterials have been the object of intense study due to promising applications in a number of different disciplines. In particular, medicine and biology have seen the potential of these novel materials with their nanoscale properties for use in ...
A Fleming +19 more
core +1 more source
Journal of Pharmacy and Bioallied Sciences, 2012 The aim of the present work is to formulate and evaluate in situ oral topical gels of poorly water soluble drug Bifonazole based on temperature induced systems for the treatment of oral candidiasis.
Dimendra Patel +4 more
doaj +1 more source
Dissolution enhancement of gliclazide using pH change approach in presence of twelve stabilizers with various physico-chemical properties [PDF]
, 2009 Purpose. The micronization using milling process to enhance dissolution rate is extremely inefficient due to a high energy input, and disruptions in the crystal lattice which can cause physical or chemical instability.
Mostafavi, Seyed Abolfazl +3 more
core +3 more sources