Results 41 to 50 of about 7,969,000 (286)
Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
Journal of Pharmacy and Bioallied Sciences, 2012 The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process.
Divyesh Thakar +2 more
doaj +1 more source
Molecules, 2022 At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions,
Arvind Sharma +10 more
doaj +1 more source
VARIOUS TECHNIQUES ENHANCING BIOAVAILABILTY OF POORLY WATER SOLUBLE DRUGS [PDF]
, 2013 A drug administered in solution form immediately available for absorption and efficiently absorbed than the same amount of drug administered in a tablet or capsule form.
Nirmala, Nirmala +2 more
core +1 more source
A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution
Asian Journal of Pharmaceutical Sciences, 2015 To enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated.
Pornsak Sriamornsak +4 more
doaj +1 more source
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Vorinostat is a histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) with anticancer properties. However, it is plagued by low water solubility, low permeability (BCS class IV drug), and suboptimal pharmacokinetics. The purpose
Ashok Kumar Janakiraman +4 more
doaj +1 more source
In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs
European Journal of Pharmaceutical Sciences, 2000 Although several routes of administration can be considered for new drug entities, the most popular remains the oral route. To predict the in vivo performance of a drug after oral administration from in vivo data, it is essential that the limiting factor to absorption can be modelled in vitro.
Dressman, J.B., Reppas, C.
openaire +3 more sources
Molecules, 2016 The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative ...
Kyeong-Ok Choi +3 more
doaj +1 more source
Solubilization of Poorly Water-soluble Drugs with Amphiphilic Phospholipid Polymers
YAKUGAKU ZASSHI, 2023 Most drug candidates developed in recent years are poorly water-soluble, which is a key challenge in pharmaceutical science. Various solubilization methods have been investigated thus far, most of which require solubilizers that provide a local hydrophobic environment wherein a drug can dissolve or induce interactions with drug molecules.
Kensuke, Yoshie, Kazuhiko, Ishihara
openaire +2 more sources
Journal of Advanced Pharmaceutical Technology & Research, 2010 In titrimetric analysis costlier organic solvents are more often employed to solubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of such solvents.
R K Maheshwari, Shruti Moondra
doaj +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source