Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs [PDF]
Pharmaceuticals, 2022 The processes of solubilization and controlled release of drugs that are poorly soluble in water are highly relevant in drug preformulation studies in pharmaceutical development [...]
M. A. Peña
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Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2018 Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang +3 more
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Recent Technologies for Amorphization of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2021 Amorphization technology has been the subject of continuous attention in the pharmaceutical industry, as a means to enhance the solubility of poorly water-soluble drugs. Being in a high energy state, amorphous formulations generally display significantly
Dohyun Kim +6 more
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Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2020 Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions.
Thao T. D. Tran, Phuong H. L. Tran
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Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium [PDF]
Pharmaceutics, 2018 Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran +1 more
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Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2019 Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water ...
Thao T. D. Tran, Phuong H. L. Tran
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Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs [PDF]
Frontiers in Drug Delivery, 2023 Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy.
Popat Mohite +4 more
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Novel cationic cellulose beads for oral delivery of poorly water-soluble drugs [PDF]
International Journal of Pharmaceutics: X, 2023 Cellulose beads emerge as carriers for poorly water-soluble drugs due to their eco-friendly raw materials and favorable porous structure. However, drug dissolution may be limited by their poor swelling ability and the presence of closed pores caused by ...
Fan Xie +3 more
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Crystal engineering for poorly water-soluble drugs: From design to applications [PDF]
Acta Pharmaceutica Sinica BThe limited aqueous solubility of active pharmaceutical ingredients (APIs) remains a major challenge in drug development, severely compromising clinical performance.
An Chen +5 more
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Embedding of Poorly Water-Soluble Drugs in Orodispersible Films—Comparison of Five Formulation Strategies [PDF]
Pharmaceutics, 2022 The poor bioavailability of many newly developed active pharmaceutical ingredients (APIs) poses a major challenge in formulation development. To overcome this issue, strategies such as the preparation of amorphous solid dispersions (ASDs), and the ...
Denise Steiner +2 more
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