Recent Technologies for Amorphization of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2021 Amorphization technology has been the subject of continuous attention in the pharmaceutical industry, as a means to enhance the solubility of poorly water-soluble drugs. Being in a high energy state, amorphous formulations generally display significantly
Dohyun Kim +6 more
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Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs [PDF]
Pharmaceuticals, 2022 The processes of solubilization and controlled release of drugs that are poorly soluble in water are highly relevant in drug preformulation studies in pharmaceutical development [...]
M. A. Peña
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Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2020 Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions.
Thao T. D. Tran, Phuong H. L. Tran
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Solubilization techniques used for poorly water-soluble drugs. [PDF]
Acta Pharm Sin BAbout 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application.
Xie B, Liu Y, Li X, Yang P, He W.
europepmc +4 more sources
Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs [PDF]
Molecules, 2015 Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery.
Matthew McKenzie +5 more
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Nanocrystals for the parenteral delivery of poorly water-soluble drugs. [PDF]
Curr Opin Solid State Mater Sci, 2012 Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications.
Sun B, Yeo Y.
europepmc +5 more sources
Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium [PDF]
Pharmaceutics, 2018 Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran +1 more
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Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2019 Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water ...
Thao T. D. Tran, Phuong H. L. Tran
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Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs [PDF]
Frontiers in Drug Delivery, 2023 Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy.
Popat Mohite +4 more
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Novel cationic cellulose beads for oral delivery of poorly water-soluble drugs [PDF]
International Journal of Pharmaceutics: X, 2023 Cellulose beads emerge as carriers for poorly water-soluble drugs due to their eco-friendly raw materials and favorable porous structure. However, drug dissolution may be limited by their poor swelling ability and the presence of closed pores caused by ...
Fan Xie +3 more
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