Results 21 to 30 of about 39,809 (238)

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine

Pharmaceuticals, 2023
The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body.
Alexey Noev, Natalia Morozova, Nikita Suvorov, Yuriy Vasil’ev, Andrei Pankratov, Mikhail Grin   +5 more
doaj   +1 more source

Co-Amorphous System: A promising Strategy for Delivering Poorly Water - Soluble Drugs

Iraqi Journal of Pharmaceutical Sciences, 2020
Amorphization of drug has been considered as an attractive approach in improving drug solubility and bioavailability. Unlike their crystalline counterparts, amorphous materials lack the long-range order of molecular packing and present the highest energy
Eman S. Aldahhan, Ameera A. Radhi
doaj   +1 more source

Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin

Pharmaceutics, 2023
The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility issues.
María Elena Gamboa-Arancibia, Nelson Caro, Alexander Gamboa, Javier Octavio Morales, Jorge Enrique González Casanova, Diana Marcela Rojas Gómez, Sebastián Miranda-Rojas   +6 more
doaj   +1 more source

Lipid nanoparticles for the delivery of poorly water-soluble drugs [PDF]

Journal of Pharmacy and Pharmacology, 2010
Abstract Objectives This review discusses important aspects of lipid nanoparticles such as colloidal lipid emulsions and, in particular, solid lipid nanoparticles as carrier systems for poorly water-soluble drugs, with a main focus on the parenteral and peroral use of these carriers.
openaire   +2 more sources

Ternary Solid Dispersions: A Review of the Preparation, Characterization, Mechanism of Drug Release, and Physical Stability

Pharmaceutics, 2023
The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman, Eli Lailasari, Neng Vera Nurani, Ellen Nathania Yunita, Gracia Anastasya, Rizqa Nurul Aulia, Ira Novianty Lestari, Laila Subra, Diah Lia Aulifa   +8 more
doaj   +1 more source

Solubility Enhancement of Poorly Water Soluble Drug

, 2023
The Biopharmaceutical Classification System includes solubility as one of its core criteria, and dissolution rate is the most crucial variable affecting a drug's bioavailability. A weakly water-soluble medication is defined as a substance with a solubility of less than 1 part per 10,000 parts of water.
Madkaikar S.A., Shukla U.D.
openaire   +2 more sources

Evaluation of Poorly Soluble Drugs’ Dissolution Rate by Laser Scattering in Different Water Isotopologues

Molecules, 2021
The most important task in the design of dosage forms is to modify the pharmaceutical substances structure in order to increase solubilization, targeted delivery, controlled rate of drug administration, and its bioavailability.
Elena V. Uspenskaya, Tatiana V. Pleteneva, Ilaha V. Kazimova, Anton V. Syroeshkin   +3 more
doaj   +1 more source

Enhanced Dissolution and Oral Bioavailability of Piroxicam Formulations: Modulating Effect of Phospholipids

Pharmaceutics, 2010
Several biologically relevant phospholipids were assessed as potential carriers/additives for rapidly dissolving solid formulations of piroxicam (Biopharmaceutics Classification System Class II drug).
Muhammad D. Hussain, Inna Miroshnyk, James F. Brausch, Muhammad J. Habib, Sabiruddin Mirza   +4 more
doaj   +1 more source

A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion Technology for Poorly Water-Soluble Drugs

Colloids and Interfaces
The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% of new drugs face market entry challenges due to low water solubility.
Zaid Dahma, Covadonga Álvarez-Álvarez, Paloma Marina de la Torre-Iglesias   +2 more
doaj   +1 more source