Results 21 to 30 of about 45,385 (279)
Colloids and InterfacesThe solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% of new drugs face market entry challenges due to low water solubility.
Zaid Dahma +2 more
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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS
INDONESIAN JOURNAL OF PHARMACY, 2014 Aqueous solubility is a limiting factor in the oral bioavailability of a certain class of poorly water soluble drugs. A consequence of low aqueous solubility is a slow dissolution rate. For the drugs with low aqueous solubility and high permeability the dissolution rate will be the rate limiting step for absorption.
Gohil, Tushar; Shree Leuva Patel Trust Pharmacy Mahila College University Saurashtra, Gujarat, 388001, India
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Lipid nanoparticles for the delivery of poorly water-soluble drugs [PDF]
Journal of Pharmacy and Pharmacology, 2010 Abstract Objectives This review discusses important aspects of lipid nanoparticles such as colloidal lipid emulsions and, in particular, solid lipid nanoparticles as carrier systems for poorly water-soluble drugs, with a main focus on the parenteral and peroral use of these carriers.
Heike Bunjes
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Lipid nanoparticles for administration of poorly water soluble neuroactive drugs
Biomedical Microdevices, 2017 This study describes the potential of solid lipid nanoparticles and nanostructured lipid carriers as nano-formulations to administer to the central nervous system poorly water soluble drugs. Different neuroactive drugs, i.e. dimethylfumarate, retinyl palmitate, progesterone and the endocannabinoid hydrolysis inhibitor URB597 have been studied.
ESPOSITO, Elisabetta +10 more
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Cubosomes as an oral drug delivery system [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2023 Oral administration is widely accepted drug delivery system however, its use is limited due to physico-chemical properties of the drug such as poor solubility, low permeability, instability, and rapid metabolism as all of which decrease oral ...
Esraa salem +3 more
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Phytomedicine Plus, 2021 Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani +6 more
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Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine
Pharmaceuticals, 2023 The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body.
Alexey Noev +5 more
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Co-Amorphous System: A promising Strategy for Delivering Poorly Water - Soluble Drugs
Iraqi Journal of Pharmaceutical Sciences, 2020 Amorphization of drug has been considered as an attractive approach in improving drug solubility and bioavailability. Unlike their crystalline counterparts, amorphous materials lack the long-range order of molecular packing and present the highest energy
Eman S. Aldahhan, Ameera A. Radhi
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Evaluation of lipid-based formulations of poorly water-soluble drugs in the gastro-intestinal tract using in vitro tests [PDF]
, 2011 Novel active pharmaceutical ingredients are often poorly water-soluble. Such compounds may only partially dissolve or may precipitate during intestinal passage, potentially leading to incomplete drug absorption. Despite the importance of the process, the
Arnold, Yvonne Elisabeth
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Drug-excipient-shell interactions using thermoplastic starch-based capsules for oral lipid-based drug delivery [PDF]
, 2014 Worldwide, gelatin has been used in the rotary die process as a shell-forming material of soft capsules due to its unique physicochemical properties.
Misic, Zdravka
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