Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges [PDF]
Pharmaceutics, 2018 Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs.
Anagha Bhakay +3 more
doaj +2 more sources
Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs [PDF]
Pharmaceutics, 2019 Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic ...
Phuong Tran +5 more
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Lipid nanoparticles for administration of poorly water soluble neuroactive drugs
Biomedical Microdevices, 2017 This study describes the potential of solid lipid nanoparticles and nanostructured lipid carriers as nano-formulations to administer to the central nervous system poorly water soluble drugs. Different neuroactive drugs, i.e.
Markus Drechsler +40 more
core +6 more sources
Cubosomes as an oral drug delivery system [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2023 Oral administration is widely accepted drug delivery system however, its use is limited due to physico-chemical properties of the drug such as poor solubility, low permeability, instability, and rapid metabolism as all of which decrease oral ...
Esraa salem +3 more
doaj +1 more source
Drug delivery strategies for poorly water-soluble drugs [PDF]
Expert Opinion on Drug Delivery, 2007 The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or
Alfred, Fahr, Xiangli, Liu
openaire +2 more sources
Phytomedicine Plus, 2021 Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani +6 more
doaj +1 more source
Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine
Pharmaceuticals, 2023 The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body.
Alexey Noev +5 more
doaj +1 more source
Co-Amorphous System: A promising Strategy for Delivering Poorly Water - Soluble Drugs
Iraqi Journal of Pharmaceutical Sciences, 2020 Amorphization of drug has been considered as an attractive approach in improving drug solubility and bioavailability. Unlike their crystalline counterparts, amorphous materials lack the long-range order of molecular packing and present the highest energy
Eman S. Aldahhan, Ameera A. Radhi
doaj +1 more source
Evaluation of lipid-based formulations of poorly water-soluble drugs in the gastro-intestinal tract using in vitro tests [PDF]
, 2011 Novel active pharmaceutical ingredients are often poorly water-soluble. Such compounds may only partially dissolve or may precipitate during intestinal passage, potentially leading to incomplete drug absorption. Despite the importance of the process, the
Arnold, Yvonne Elisabeth
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Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]
, 2013 In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
core +1 more source