Results 11 to 20 of about 7,280,281 (268)
Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs [PDF]
Molecules, 2015 Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery.
Matthew McKenzie +5 more
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Drug Delivery Strategies for Poorly Water-Soluble Drugs [PDF]
, 2013 Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients.
Douroumis, Dionysios
core +8 more sources
Solubilization techniques used for poorly water-soluble drugs. [PDF]
Acta Pharm Sin BAbout 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application.
Xie B, Liu Y, Li X, Yang P, He W.
europepmc +4 more sources
Nanocrystals for the parenteral delivery of poorly water-soluble drugs. [PDF]
Curr Opin Solid State Mater Sci, 2012 Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications.
Sun B, Yeo Y.
europepmc +5 more sources
Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs [PDF]
Molecules, 2022 At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions,
Arvind Sharma +10 more
doaj +2 more sources
Colloids and InterfacesThe solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% of new drugs face market entry challenges due to low water solubility.
Zaid Dahma +2 more
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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS [PDF]
INDONESIAN JOURNAL OF PHARMACY, 2014 Aqueous solubility is a limiting factor in the oral bioavailability of a certain class of poorly water soluble drugs. A consequence of low aqueous solubility is a slow dissolution rate.
Gohil, Tushar; Shree Leuva Patel Trust Pharmacy Mahila College University Saurashtra, Gujarat, 388001, India
core +4 more sources
In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging [PDF]
Acta Pharmaceutica Sinica B, 2021 In vitro‒in vivo correlation (IVIVC) of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients. Nevertheless, in vivo dissolution profiles have never been accurately portrayed. The
Yinqian Yang +9 more
doaj +2 more sources
Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs
Asian Journal of Pharmaceutical Sciences, 2015 Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness ...
Varaporn Buraphacheep Junyaprasert +1 more
doaj +3 more sources
Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs [PDF]
Asian Journal of Pharmaceutical SciencesWhile spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce
Jung Suk Kim +12 more
doaj +2 more sources