Crystal engineering for poorly water-soluble drugs: From design to applications [PDF]
Acta Pharmaceutica Sinica BThe limited aqueous solubility of active pharmaceutical ingredients (APIs) remains a major challenge in drug development, severely compromising clinical performance.
An Chen +5 more
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Embedding of Poorly Water-Soluble Drugs in Orodispersible Films—Comparison of Five Formulation Strategies [PDF]
Pharmaceutics, 2022 The poor bioavailability of many newly developed active pharmaceutical ingredients (APIs) poses a major challenge in formulation development. To overcome this issue, strategies such as the preparation of amorphous solid dispersions (ASDs), and the ...
Denise Steiner +2 more
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Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs [PDF]
Molecules, 2022 At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions,
Arvind Sharma +10 more
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Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs
Asian Journal of Pharmaceutical Sciences, 2015 Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness ...
Varaporn Buraphacheep Junyaprasert +1 more
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In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging [PDF]
Acta Pharmaceutica Sinica B, 2021 In vitro‒in vivo correlation (IVIVC) of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients. Nevertheless, in vivo dissolution profiles have never been accurately portrayed. The
Yinqian Yang +9 more
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Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs [PDF]
Asian Journal of Pharmaceutical SciencesWhile spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce
Jung Suk Kim +12 more
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Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2018 Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang +3 more
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Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges [PDF]
Pharmaceutics, 2018 Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs.
Anagha Bhakay +3 more
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Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs [PDF]
Pharmaceutics, 2019 Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic ...
Phuong Tran +5 more
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Drug delivery strategies for poorly water-soluble drugs [PDF]
Expert Opinion on Drug Delivery, 2007 The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or
Alfred, Fahr, Xiangli, Liu
openaire +3 more sources