Results 31 to 40 of about 45,385 (279)
Self - Emulsifying Drug Delivery System: A Novel Approach for Oral Delivery of Poorly Water Soluble Drugs [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2021 Self nano emulsifying drug delivery systems (SNEDDs) gained much attention in the last decades since, such systems considered one of the most favorable and efficient approaches to enhance solubility, increase drug absorption and hence, enhance its oral ...
Ahmed Nasef
doaj +1 more source
Pharmaceutics, 2023 The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility issues.
María Elena Gamboa-Arancibia +6 more
doaj +1 more source
Solubility Enhancement of Poorly Water Soluble Drug
, 2023 The Biopharmaceutical Classification System includes solubility as one of its core criteria, and dissolution rate is the most crucial variable affecting a drug's bioavailability. A weakly water-soluble medication is defined as a substance with a solubility of less than 1 part per 10,000 parts of water.
Madkaikar S.A., Shukla U.D.
openaire +2 more sources
Pharmaceutics, 2023 The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman +8 more
doaj +1 more source
Insights into the biopharmaceutical behavior of oral lipid-based formulations using advanced analytical techniques and mathematical modeling [PDF]
, 2014 Lipid-based formulations (LBFs) are effective means for the oral delivery of poorly water-soluble compounds. The drug is already solubilized in the formulation and, thus, the critical dissolution step is circumvented. However, the oral bioavailability is
Stillhart, Cordula Edith
core +1 more source
Pharmaceutics, 2010 Several biologically relevant phospholipids were assessed as potential carriers/additives for rapidly dissolving solid formulations of piroxicam (Biopharmaceutics Classification System Class II drug).
Muhammad D. Hussain +4 more
doaj +1 more source
Molecules, 2021 The most important task in the design of dosage forms is to modify the pharmaceutical substances structure in order to increase solubilization, targeted delivery, controlled rate of drug administration, and its bioavailability.
Elena V. Uspenskaya +3 more
doaj +1 more source
Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds?
, 2013 In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
core +1 more source
ADMET and DMPK, 2019 The purpose of the present study was to harmonize the protocol of equilibrium solubility measurements for poorly water-soluble drugs to lower inter-laboratory variance.
Asami Ono +15 more
doaj +1 more source
In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs
European Journal of Pharmaceutical Sciences, 2000 Although several routes of administration can be considered for new drug entities, the most popular remains the oral route. To predict the in vivo performance of a drug after oral administration from in vivo data, it is essential that the limiting factor to absorption can be modelled in vitro.
Dressman, J.B., Reppas, C.
openaire +3 more sources