Results 31 to 40 of about 39,809 (238)
ADMET and DMPK, 2019 The purpose of the present study was to harmonize the protocol of equilibrium solubility measurements for poorly water-soluble drugs to lower inter-laboratory variance.
Asami Ono +15 more
doaj +1 more source
In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs
European Journal of Pharmaceutical Sciences, 2000 Although several routes of administration can be considered for new drug entities, the most popular remains the oral route. To predict the in vivo performance of a drug after oral administration from in vivo data, it is essential that the limiting factor to absorption can be modelled in vitro.
Dressman, J.B., Reppas, C.
openaire +3 more sources
Insoluble drug delivery strategies: review of recent advances and business prospects
Acta Pharmaceutica Sinica B, 2015 The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
Sandeep Kalepu, Vijaykumar Nekkanti
doaj +1 more source
Solubilization of Poorly Water-soluble Drugs with Amphiphilic Phospholipid Polymers
YAKUGAKU ZASSHI, 2023 Most drug candidates developed in recent years are poorly water-soluble, which is a key challenge in pharmaceutical science. Various solubilization methods have been investigated thus far, most of which require solubilizers that provide a local hydrophobic environment wherein a drug can dissolve or induce interactions with drug molecules.
Kensuke, Yoshie, Kazuhiko, Ishihara
openaire +2 more sources
Nanosuspension: An approach to enhance solubility of drugs
Journal of Advanced Pharmaceutical Technology & Research, 2011 One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media ...
Vishal R Patel, Y K Agrawal
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Development of Liquisolid Technology to Overcome Dissolution/Absorption Limitations of Oral Drugs
Pharmaceutical FrontsIncreasing influx of poorly water-soluble drugs poses a significant challenge to oral drug delivery. Conventional solubilization techniques such as solid dispersion and cyclodextrin inclusion, while capable of improving drug dissolution, suffer from a ...
Huan Wang, Xingwang Zhang
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Overview of milling techniques for improving the solubility of poorly water-soluble drugs
Asian Journal of Pharmaceutical Sciences, 2015 Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles.
Zhi Hui Loh +2 more
doaj +1 more source