Results 51 to 60 of about 7,280,281 (268)

Nanosuspension: An approach to enhance solubility of drugs

Journal of Advanced Pharmaceutical Technology & Research, 2011
One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media ...
Vishal R Patel, Y K Agrawal
doaj   +1 more source

Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection [PDF]

, 2020
Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on this solubilization interplay using proton nuclear magnetic resonance ...
Pöppler, A., Galli, Bruno, Meinel, Lorenz, Harlacher, C., Meinel, L., Schlauersbach, Jonas, Lenz, B., Vemulapalli, S., Vemulapalli, Sahithya P. B., Vemulapalli, Sahithya P B, Hanio, Simon, Hanio, S., Lenz, Bettina, Pöppler, Ann-Christin, Griesinger, C. ; https://orcid.org/, Vemulapalli, Sahithya, Schlauersbach, J., Galli, B., Harlacher, Cornelius, Griesinger, Christian   +19 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Development of deep eutectic solvent systems and their formulation: Assessment of solubilization potential on poorly water-soluble drugs. [PDF]

Modern strategies to deliver drugs efficiently via less toxic non-aqueous carriers like deep eutectic solvents (DES) has grown tremendously. Herein, we develop several synthetic and natural DES to improve solubility of poorly soluble drug, docetaxel (DTX)
Sameer, Sonkusale, Rachel , Owyeung, Brijesh, Shah   +2 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Solubilization of Insoluble and Poorly-Water Soluble Drugs in Micellar Systems

Pharmedicine Journal
Introduction: This study investigates the micellar solubilization of several insoluble and poorly soluble drugs—clopidogrel bisulfate, ganciclovir sodium, miconazole nitrate, brinzolamide, brimonidine tartarate, and dexamethasone—using sodium dodecyl ...
Sinem Gokturk, Cuneyt Toprak
doaj   +1 more source

Overview of milling techniques for improving the solubility of poorly water-soluble drugs

Asian Journal of Pharmaceutical Sciences, 2015
Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles.
Zhi Hui Loh, Asim Kumar Samanta, Paul Wan Sia Heng   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source