Results 71 to 80 of about 45,385 (279)
Pharmaceutics, 2020 Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process.
Hui-Won Cho +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
Strategies for formulating and delivering poorly water-soluble drugs
, 2015 Water solubility is a key parameter in drug formulation since it highly influences drug pharmacokinetics and pharmacodynamics. In the past decades, the challenge with poorly water soluble drugs has been growing continuously.
Rodriguez Aller, Marta Ruth +3 more
core +1 more source
A nanocrystal technology: to enhance solubility of poorly water soluble drugs
Journal of Applied Pharmaceutical Research, 2017 Most of the recently developed new chemical entities are poorly water soluble and they create major problems during formulation and development of new dosage form and due to poor solubility and poor bioavailability.
R M Mirza, S P Ahirrao, S. J. Kshirsagar
doaj
Advanced Functional Materials, EarlyView.An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández +14 more
wiley +1 more source
Development of a New Ex Vivo Lipolysis-Absorption Model for Nanoemulsions
Pharmaceutics, 2019 The use of lipid-based formulations (LBFs) in improving the absorption of poorly water-soluble drugs has now well established. Because the in vivo evaluation of LBFs is labor-intensive, in vitro or ex vivo approaches could provide advantages.
Lu Xiao, Ying Liu, Tao Yi
doaj +1 more source
Advanced Functional Materials, EarlyView.A molecular shielding strategy to convert “protein‐sticky” and “non‐tumor specific” clinical ICG dye, into a “low protein binding” and “tumor‐targeting” dye with prolonged blood circulation and renal clearance is described. These shielded ICGs demonstrate strong tumor accumulation and optimal tissue clearance, resulting in high tumor‐to‐background ...
Li Xiang +9 more
wiley +1 more source
Nanosuspension: An emerging trend to improve solubility of poorly water soluble drugs
, 2019 There are various parameters like solubility, stability, compatibility, excipient, and photostability which affects formulation of drugs, but solubility plays an important role for drug formulation. Most of newly discovered drugs are poorly water soluble.
Vedaga, S. B. +2 more
core +1 more source
Mechanistic study of physicochemical and biochemical processes affecting intestinal absorption of the sesquiterpene lactone nobilin from multi-component systems in the Caco-2 model [PDF]
, 2015 The overall aim of this work was to investigate the intestinal absorption of the sesquiterpene lactone nobilin from the flowers of Anthemis nobilis L.
Thormann, U.
core +1 more source
Solubility Enhancement of Poorly Water-Soluble Drugs
International Journal of Advanced Research in Science, Communication and TechnologyThis article provides an overview of nanocrystals as a potentially valuable technology for enhancing the solubility of water-insoluble pharmaceuticals. Nanocrystals increase surface area by reducing particle size, hence improving bioavailability and solubility.
null Mr. Sufiyan Ahemad Abdul Mukthar +1 more
openaire +1 more source