Results 91 to 100 of about 7,280,281 (268)

Nanoparticle formulations of poorly water soluble drugs and their action in vivo and in vitro [PDF]

, 2007
textPoorly water soluble drugs have been manipulated to make them more soluble, increasing the bioavailability of these drugs. Several cryogenic processes allow for production of drug nanoparticles, without mechanical stress that could cause degradation.
Purvis, Troy Powell
core  

In Situ Interfacial Assembly of Dynamic Semi‐Interpenetrating Biopolymer Networks for Robust and Mechanically Adaptive Droplet Interfaces

Advanced Functional Materials, EarlyView.
A dynamic interfacial semi‐interpenetrating polymer network is constructed by sequential assembly of β‐sheet‐rich SF and CS‐RL. The SF framework provides mechanical strength, while dynamically associated CS‐RL enables local rearrangement, allowing droplets to rapidly reconfigure without loss of interfacial integrity.
Yaping Zhang, Yujie Liu, Yikai Xu, Xunda Feng, Ling Zhang, Hongbo Zeng, Hao Liu, Xiaohui Mao   +7 more
wiley   +1 more source

Selenium‐Integrated Cyanine Dye With Enhanced Photophysical Properties for Optoacoustic‐Guided Cancer Imaging and Therapy

Advanced Functional Materials, EarlyView.
This study introduces selenium‐integrated cyanine dye (Se‐Cyn), with superior photostability, absorption, and photothermal efficiency, outperforming ICG in NIR window. Its nanoparticle form remains stable in water, accumulates in tumors, and enables strong optoacoustic imaging and effective phototherapy outcomes.
Divyesh Shelar, Snehal Salunkhe, Tony Fröhlich, Uwe Klemm, Pia Anzenhofer, Birgit Rathkolb, Martin Hrabě de Angelis, Oliver Plettenburg, Michael Sattler, Sudesh T. Manjare, Vipul Gujrati, Vasilis Ntziachristos   +11 more
wiley   +1 more source

Strategies for formulating and delivering poorly water-soluble drugs

, 2015
Water solubility is a key parameter in drug formulation since it highly influences drug pharmacokinetics and pharmacodynamics. In the past decades, the challenge with poorly water soluble drugs has been growing continuously.
Rodriguez Aller, Marta Ruth, Guillarme, Davy, Veuthey, Jean-Luc, Gurny, Robert   +3 more
core   +1 more source

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source

Enhancement of solubility of poorly soluble drugs by solid dispersion: An Overview [PDF]

, 2017
Most of the newly invented chemical drug moieties are poorly water soluble. According to BCS classification, class II and IV drugs are considered as poorly water soluble. So enhancement of oral absorption and bioavailability of solid dosage forms remains
Thyagaraju, K., Katta Manogna, P. Nagaveni, K. Thyagaraju, Manogna, Katta, Nagaveni, P.   +5 more
core   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

Risk Assessment of Factors Affecting Physical and Chemical Stability of Solid Dispersions of Poorly-Soluble Drugs

مجلة بغداد للعلوم
Solid dispersions are one of the most promising strategies to overcome the poor aqueous solubility of some drug substances. However, the physical and chemical instability of solid dispersions has limited their use. The purpose of this study was to assess
Iyad H Allous, Shuaib I Alahmad, Youssef S Alahmad, Mirvat A Mourad   +3 more
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Formulation strategies for pulmonary delivery of poorly soluble drugs

, 2015
Poorly water-soluble drugs represent the major part of the current and future market. Drug insolubility could impair the absorption through biological membranes and/or the pharmacological action of the drug.
Nathalie Wauthoz, Amighi, Karim, Karim Amighi, Wauthoz, Nathalie   +3 more
core   +1 more source