Results 1 to 10 of about 261,112 (210)
Oral Bioavailability of Monoclonal Antibody [PDF]
PharmaceuticsBackground/Objectives: Despite significant interest in the oral delivery of antibodies, the oral bioavailability of monoclonal antibodies (mAbs) is not known to date.
Ashwni Verma +2 more
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The influence of the gut microbiota on the bioavailability of oral drugs
Acta Pharmaceutica Sinica B, 2021 Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract.
Xintong Zhang +4 more
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Strategies to Overcome Heparins’ Low Oral Bioavailability
Pharmaceuticals, 2016 Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over
Ana Rita Neves +3 more
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Oral Bioavailability Enhancement of Anti-Cancer Drugs Through Lipid Polymer Hybrid Nanoparticles [PDF]
PharmaceuticsCancer is considered as the second leading cause of death worldwide. Chemotherapy, radiotherapy, immunotherapy, and targeted drug delivery are the main treatment options for treating cancers. Chemotherapy drugs are either available for oral or parenteral
Saud Almawash
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Drug Delivery, 2017 Fisetin (FST), a potent anticancer phytoconstituent, exhibits poor aqueous solubility and hence poor bioavailability. The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid
Amrita Kadari +6 more
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Comparison of Solid Self-Nanoemulsifying Systems and Surface-Coated Microspheres: Improving Oral Bioavailability of Niclosamide [PDF]
International Journal of NanomedicineKyungho Baek,1 Mi Ran Woo,2 Fakhar ud Din,3 Yong Seok Choi,4 Myung Joo Kang,4 Jong Oh Kim,5 Han-Gon Choi,2 Sung Giu Jin1 1Department of Pharmaceutical Engineering, Dankook University, Cheonan, South Korea; 2College of Pharmacy, Hanyang University, Ansan,
Baek K +7 more
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Absorption and Bioavailability of Novel UltraShear Nanoemulsion of Cannabidiol in Rats
Medical Cannabis and Cannabinoids, 2023 Introduction: Cannabidiol (CBD) has several potential benefits and therapeutic uses, especially in pain, inflammation, and anxiety. CBD has high hydrophobicity and very low solubility in water.
Mahmoud A. ElSohly +2 more
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Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2023 In terms of drug delivery methods, oral administration stands out as the preferred option, as it ensures better patient compliance. However, the challenges of poor water solubility and limited metabolic/enzymatic stability hinder the effectiveness of ...
C. Thangam +5 more
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Systems biological approach of molecular descriptors connectivity: optimal descriptors for oral bioavailability prediction. [PDF]
PLoS ONE, 2012 Poor oral bioavailability is an important parameter accounting for the failure of the drug candidates. Approximately, 50% of developing drugs fail because of unfavorable oral bioavailability.
Shiek S S J Ahmed, V Ramakrishnan
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Journal of Ginseng Research, 2023 Panax ginseng Meyer is a traditional Chinese medicine that is widely used as tonic in Asia. The main pharmacologically active components of ginseng are the dammarane-type ginsenosides, which have been shown to have anti-cancer, anti-inflammatory ...
Qi-rui Hu +7 more
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