Results 1 to 10 of about 1,626,235 (296)
Oral Bioavailability of Monoclonal Antibody. [PDF]
PharmaceuticsBackground/Objectives: Despite significant interest in the oral delivery of antibodies, the oral bioavailability of monoclonal antibodies (mAbs) is not known to date. To find out an answer to this question, we have performed a preclinical investigation in mice and rats, using a non-binding humanized mAb trastuzumab as the prototype molecule.
Verma A, Wu S, Shah DK.
europepmc +6 more sources
Strategies to Overcome Heparins’ Low Oral Bioavailability
Pharmaceuticals, 2016 Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over
Ana Rita Neves +2 more
exaly +4 more sources
The influence of the gut microbiota on the bioavailability of oral drugs
Acta Pharmaceutica Sinica B, 2021 Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract.
Xintong Zhang +2 more
exaly +3 more sources
Oral Bioavailability Enhancement of Anti-Cancer Drugs Through Lipid Polymer Hybrid Nanoparticles. [PDF]
PharmaceuticsCancer is considered as the second leading cause of death worldwide. Chemotherapy, radiotherapy, immunotherapy, and targeted drug delivery are the main treatment options for treating cancers. Chemotherapy drugs are either available for oral or parenteral
Almawash S.
europepmc +2 more sources
Absorption and Bioavailability of Novel UltraShear Nanoemulsion of Cannabidiol in Rats
Medical Cannabis and Cannabinoids, 2023 Introduction: Cannabidiol (CBD) has several potential benefits and therapeutic uses, especially in pain, inflammation, and anxiety. CBD has high hydrophobicity and very low solubility in water.
Mahmoud A. ElSohly +2 more
doaj +1 more source
Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2023 In terms of drug delivery methods, oral administration stands out as the preferred option, as it ensures better patient compliance. However, the challenges of poor water solubility and limited metabolic/enzymatic stability hinder the effectiveness of ...
C. Thangam +5 more
doaj +1 more source
Systems biological approach of molecular descriptors connectivity: optimal descriptors for oral bioavailability prediction. [PDF]
PLoS ONE, 2012 Poor oral bioavailability is an important parameter accounting for the failure of the drug candidates. Approximately, 50% of developing drugs fail because of unfavorable oral bioavailability.
Shiek S S J Ahmed, V Ramakrishnan
doaj +1 more source
Bioavailability of oral curcumin [PDF]
Canadian Medical Association Journal, 2019 In our research article, we conclude that the regimen of curcumin we tested exerted no beneficial pharmacodynamic effect on the outcomes we assessed in the setting of elective abdominal aortic aneurysm repair.[1][1] These findings advance knowledge. Dr.
Amit X, Garg +5 more
openaire +2 more sources
Journal of Ginseng Research, 2023 Panax ginseng Meyer is a traditional Chinese medicine that is widely used as tonic in Asia. The main pharmacologically active components of ginseng are the dammarane-type ginsenosides, which have been shown to have anti-cancer, anti-inflammatory ...
Qi-rui Hu +7 more
doaj +1 more source
Iraqi Journal of Pharmaceutical Sciences, 2023 Piperine, a crystalline alkaloid compound isolated from Piper nigrum, piper longum, and other types of piper, has had many fabulous pharmacological advantages for preventing and treating some specific diseases, such as analgesic, anti-inflammatory ...
Akhmad Kharis Nugroho +3 more
doaj +1 more source