Results 31 to 40 of about 162,747 (308)

Influence of chitosan coating on the oral bioavailability of gold nanoparticles in rats

Saudi Pharmaceutical Journal, 2019
Gold nanoparticles are one of the most extensively investigated metallic nanoparticles for several applications. It is less toxic than other metallic nanolattices.
Ahmed Alalaiwe, Paul Carpinone, Saad Alshahrani, Bader Alsulays, Mohammed Ansari, Mohammed Anwer, Sultan Alshehri, Abdullah Alshetaili   +7 more
doaj   +1 more source

Solubilization of Paclitaxel with Natural Compound Rubusoside toward Improving Oral Bioavailability in a Rodent Model

Pharmaceutics
Paclitaxel, which features low water solubility and permeability, is an efflux pump substrate. The current paclitaxel drugs are given intravenously after resolving the solubility issue.
Jian Zhang, Jicheng Shu, Rhett W. Stout, Paul S. Russo, Zhijun Liu   +4 more
doaj   +1 more source

Research Progress on Oral Nano-formulation to Deliver Astaxanthin

Shipin gongye ke-ji
Astaxanthin is a fat-soluble lutein carotenoid with good antioxidant, anti-inflammatory and immunomodulatory activities. However, its poor oral bioavailability lead to limited clinical application.
Chen ZHONG, Mei LIU, Yan GAO, Kefeng XU, Ying WANG   +4 more
doaj   +1 more source

Pickering Emulsions Enhance Oral Bioavailability of Curcumin Nanocrystals: The Effect of Oil Types

Pharmaceutics, 2023
Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs in the Biopharmaceutical Classification System (BCS) due to the absorption of the intact crystals. The performance is compromised by the dissolution of NCs.
Yuze Sheng, Qin Yu, Yanping Huang, Quangang Zhu, Zhongjian Chen, Wei Wu, Tao Yi, Yi Lu   +7 more
doaj   +1 more source

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability [PDF]

, 2017
Famotidine as H-2 receptor has antagonistic effects on gastric secretion. Unfortunately, its hydrophobic nature contributes to its variable and poor oral bioavailability.
Shafique, Muhammad, Mir Azam Khan, Waheed S. Khan, Maqsood-ur-Rehman, Khan, Mir Azam, Shahzeb Khan, Waqar Ahmad, Ahmad, Waqar, Khan, Waheed S., Muhammad Shafique, Khan, Shahzeb, null Maqsood-ur-Rehman   +11 more
core   +1 more source

Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review

Pharmaceutics
The oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the oral cavity, offering an alternative to enteral administration by bypassing the harsh ...
Ildikó Bácskay, Petra Arany, Pálma Fehér, Liza Józsa, Gábor Vasvári, Dániel Nemes, Ágota Pető, Dóra Kósa, Ádám Haimhoffer, Zoltán Ujhelyi, Dávid Sinka   +10 more
doaj   +1 more source

Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

Pharmaceutics, 2021
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration.
Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng   +2 more
doaj   +1 more source

Pharmacokinetics and Oral Bioavailability of Glycopyrrolate in Children [PDF]

Pharmacology & Toxicology, 1998
Abstract: Based on plasma levels determined with a radioreceptor assay and following a single oral (50 μg/kg) and intravenous (5 μg/kg) administration of glycopyrrolate in six healthy children operated twice during a several weeks period, a negligible and variable oral bioavailability was found (3.3; 1.3–13.3%) (median; range).
P, Rautakorpi, T, Manner, T, Ali-Melkkilä, T, Kaila, K, Olkkola, J, Kanto   +5 more
openaire   +2 more sources

Folate bioavailability [PDF]

, 2009
An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source