Results 11 to 20 of about 162,747 (308)

Niosomal carriers enhance oral bioavailability of carvedilol: effects of bile salt-enriched vesicles and carrier surface charge  [PDF]

International Journal of Nanomedicine, 2015
Gelareh Arzani,1 Azadeh Haeri,1 Marjan Daeihamed,1 Hamid Bakhtiari-Kaboutaraki,1 Simin Dadashzadeh1,2 1Department of Pharmaceutics, Faculty of Pharmacy, 2Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran ...
Arzani G, Haeri A, Daeihamed M, Bakhtiari-Kaboutaraki H, Dadashzadeh S   +4 more
doaj   +1 more source

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system [PDF]

International Journal of Nanomedicine, 2012
Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaBackground: Indirubin, isolated from the leaves of the Chinese herb Isatis
Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP
doaj   +2 more sources

An update on Nanoparticle Formulation Design of Piperine to Improve its Oral bioavailability: A Review

Iraqi Journal of Pharmaceutical Sciences, 2023
Piperine, a crystalline alkaloid compound isolated from Piper nigrum, piper longum, and other types of piper, has had many fabulous pharmacological advantages for preventing and treating some specific diseases, such as analgesic, anti-inflammatory ...
Akhmad Kharis Nugroho, Nindya Kusumorini, Suwijiyo Pramono, Ronny Martien   +3 more
doaj   +1 more source

Advances in Oral Drug Delivery Systems: Challenges and Opportunities

Pharmaceutics, 2023
The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and ...
Jie Lou, Hongli Duan, Qin Qin, Zhipeng Teng, Fengxu Gan, Xiaofang Zhou, Xing Zhou   +6 more
doaj   +1 more source

Pharmacokinetics and bioavailability of oral ifosfamide [PDF]

Journal of Cancer Research and Clinical Oncology, 1986
The bioavailability of oral N,3-bis(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide (ifosfamide) (500-mg gelatine capsules) was investigated in 18 patients with bronchogenic carcinoma. Oral and intravenous (Holoxan) ifosfamide was applicated in a randomized sequence on days 1 and 3 at a dose of 1 g/m2 (n = 12) and 2 g/m2 (n = 6 ...
T, Wagner, P, Drings
openaire   +2 more sources

Sodium Alginate/Chitosan-Coated Liposomes for Oral Delivery of Hydroxy-α-Sanshool: In Vitro and In Vivo Evaluation

Pharmaceutics, 2023
Background: Hydroxy-α-Sanshool (HAS) possesses various pharmacological properties, such as analgesia and regulating gastrointestinal function. However, the low oral bioavailability of HAS has limited its oral delivery in clinical application. Methods and
Fengming Tan, Huan Li, Kai Zhang, Lulu Xu, Dahan Zhang, Yang Han, Jing Han   +6 more
doaj   +1 more source

New IMB16-4 Nanoparticles Improved Oral Bioavailability and Enhanced Anti-Hepatic Fibrosis on Rats

Pharmaceuticals, 2022
Liver fibrosis is challenging to treat because of the lack of effective agents worldwide. Recently, we have developed a novel compound, N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamido) benzamide referred to as IMB16-4.
Xia Niu, Xiaomei Wang, Bingyu Niu, Yucheng Wang, Hongwei He, Guiling Li   +5 more
doaj   +1 more source

The Effect of Chemical Modifications of Chitosan on Intestinal Permeability and Oral Bioavailability of Carbamoylphosphonate JS403 [PDF]

, 2020
Art. 392, 8 S.JS403, Carbamoylphosphonate molecule, is a promising drug candidate with anti-metastatic activity. The polarityand water solubility of JS403 evolve from the phosphonate moiety that is ionized at physiologic pH.
Reich, Reuven, Bitton-Dotan, Reut, Tsuriel, Marina, Storsberg, Joachim, Hoffman, Amnon, Tulichala, RN Prasad, Bohrisch, Jörg, Breuer, Eli, Schmidt, Christian   +8 more
core   +1 more source

Heavy metal bioavailability and bioaccessibility in soil [PDF]

, 2009
This chapter considers the use of a variety of approaches to assess either the bioavailability or the bioaccessibility of metals in soil. The bioavailability of metals from soils is considered with respect to a series of single-extraction methods ...
Dean, John, John Richard Dean
core   +1 more source

Oral Bioavailability of Atenolol

Journal of International Medical Research, 1989
The bioavailability of two formulations of atenolol was compared in an open, randomized crossover study. Each film-coated tablet contained 100 mg of active drug. The plasma concentrations of atenolol were determined using a newly developed and specific high-performance liquid chromatography procedure.
H, Vergin, V, Nitsche
openaire   +2 more sources