Results 11 to 20 of about 1,626,235 (296)
International Journal of Nanomedicine, 2015 Gelareh Arzani,1 Azadeh Haeri,1 Marjan Daeihamed,1 Hamid Bakhtiari-Kaboutaraki,1 Simin Dadashzadeh1,2 1Department of Pharmaceutics, Faculty of Pharmacy, 2Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran ...
Arzani G +4 more
doaj +1 more source
Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system [PDF]
International Journal of Nanomedicine, 2012 Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaBackground: Indirubin, isolated from the leaves of the Chinese herb Isatis
Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP
doaj +1 more source
Advances in Oral Drug Delivery Systems: Challenges and Opportunities
Pharmaceutics, 2023 The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and ...
Jie Lou +6 more
doaj +1 more source
Pharmacokinetics and bioavailability of oral ifosfamide [PDF]
Journal of Cancer Research and Clinical Oncology, 1986 The bioavailability of oral N,3-bis(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide (ifosfamide) (500-mg gelatine capsules) was investigated in 18 patients with bronchogenic carcinoma. Oral and intravenous (Holoxan) ifosfamide was applicated in a randomized sequence on days 1 and 3 at a dose of 1 g/m2 (n = 12) and 2 g/m2 (n = 6 ...
T, Wagner, P, Drings
openaire +2 more sources
Pharmaceutics, 2023 Background: Hydroxy-α-Sanshool (HAS) possesses various pharmacological properties, such as analgesia and regulating gastrointestinal function. However, the low oral bioavailability of HAS has limited its oral delivery in clinical application. Methods and
Fengming Tan +6 more
doaj +1 more source
New IMB16-4 Nanoparticles Improved Oral Bioavailability and Enhanced Anti-Hepatic Fibrosis on Rats
Pharmaceuticals, 2022 Liver fibrosis is challenging to treat because of the lack of effective agents worldwide. Recently, we have developed a novel compound, N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamido) benzamide referred to as IMB16-4.
Xia Niu +5 more
doaj +1 more source
Absolute oral bioavailability of ciprofloxacin [PDF]
Antimicrobial Agents and Chemotherapy, 1986 We evaluated the absolute bioavailability of ciprofloxacin, a new quinoline carboxylic acid, in 12 healthy male volunteers. Doses of 200 mg were given to each of the volunteers in a randomized, crossover manner 1 week apart orally and as a 10-min intravenous infusion.
G L, Drusano +5 more
openaire +2 more sources
Heavy metal bioavailability and bioaccessibility in soil [PDF]
, 2009 This chapter considers the use of a variety of approaches to assess either the bioavailability or the bioaccessibility of metals in soil. The bioavailability of metals from soils is considered with respect to a series of single-extraction methods ...
Dean, John, John Richard Dean
core +1 more source
Oral Bioavailability of Atenolol
Journal of International Medical Research, 1989 The bioavailability of two formulations of atenolol was compared in an open, randomized crossover study. Each film-coated tablet contained 100 mg of active drug. The plasma concentrations of atenolol were determined using a newly developed and specific high-performance liquid chromatography procedure.
H, Vergin, V, Nitsche
openaire +2 more sources
Pharmaceuticals, 2022 Silymarin, a phyto-constituent derived from the plant Silybum marianum, has been widely acknowledged for its hepatoprotective activities. Nevertheless, its clinical utility is adversely hampered by its poor water-solubility and its limited oral ...
Ravi Gundadka Shriram +6 more
doaj +1 more source