Results 41 to 50 of about 261,112 (210)

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation [PDF]

, 2015
Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the self-emulsifying drug delivery systems.
Benda L., FRANCESCHINIS, ERICA, Perssutti B., REALDON, NICOLA, SANTOMASO, ANDREA CLAUDIO, Voinovich D.   +5 more
core   +1 more source

Research Progress on Oral Nano-formulation to Deliver Astaxanthin

Shipin gongye ke-ji
Astaxanthin is a fat-soluble lutein carotenoid with good antioxidant, anti-inflammatory and immunomodulatory activities. However, its poor oral bioavailability lead to limited clinical application.
Chen ZHONG, Mei LIU, Yan GAO, Kefeng XU, Ying WANG   +4 more
doaj   +1 more source

Pickering Emulsions Enhance Oral Bioavailability of Curcumin Nanocrystals: The Effect of Oil Types

Pharmaceutics, 2023
Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs in the Biopharmaceutical Classification System (BCS) due to the absorption of the intact crystals. The performance is compromised by the dissolution of NCs.
Yuze Sheng, Qin Yu, Yanping Huang, Quangang Zhu, Zhongjian Chen, Wei Wu, Tao Yi, Yi Lu   +7 more
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review

Pharmaceutics
The oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the oral cavity, offering an alternative to enteral administration by bypassing the harsh ...
Ildikó Bácskay, Petra Arany, Pálma Fehér, Liza Józsa, Gábor Vasvári, Dániel Nemes, Ágota Pető, Dóra Kósa, Ádám Haimhoffer, Zoltán Ujhelyi, Dávid Sinka   +10 more
doaj   +1 more source

Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

Pharmaceutics, 2021
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration.
Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng   +2 more
doaj   +1 more source

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. [PDF]

, 2011
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides.
Bauman, Jonathan N, Gelev, Vladimir M, Jacobson, Matthew P, Kalgutkar, Amit S, Leung, Siegfried SF, Linington, Roger G, Liras, Spiros, Lokey, R Scott, Mathiowetz, Alan M, McEwen, Cayla M, Price, David A, Rand, Arthur C, Renzelman, Chad M, Rezai, Taha, Turner, Rushia A, White, Tina R, Zhang, Yizhong   +16 more
core   +1 more source

Oral liquid antipsychotic formulation in the treatment of psychosis [PDF]

, 2013
This article discusses oral liquid antipsychotics as a treatment option to either oral tablets or injection formulation. It discusses bioavailability, treatment in emergencies and the potential merits of using oral liquid preparations in terms of ...
Bressington, D., Mutsatsa, S.
core   +1 more source

Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]

, 2015
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu, Oga, Enoche Florence, Sekine, Shuichi, Shitara, Yoshihisa   +3 more
core   +1 more source

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Acta Pharmaceutica Sinica B, 2019
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs.
Ying Han, Zhonggao Gao, Liqing Chen, Lin Kang, Wei Huang, Mingji Jin, Qiming Wang, You Han Bae   +7 more
doaj   +1 more source