Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach [PDF]
, 2017 Background and Objective: Short-term fasting can alter drug exposure but it is unknown whether this is an effect of altered oral bioavailability and/or systemic clearance.
Achterbergh, R. (Roos) +4 more
core +3 more sources
Design and in Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin [PDF]
, 2013 Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties.
El-Sherbiny, Ibrahim M. +3 more
core +2 more sources
Developing site-specific guidelines for orchard soils based on bioaccessibility – Can it be done? [PDF]
, 2008 Horticultural land within the periurban fringe of NZ towns and cities increasingly is being developed for residential subdivision. Recent surveys have shown that concentrations of As, Cd, Cu, Pb, and ΣDDT (sum of DDT and its degradation products DDE and ...
Gaw, Sally K. +4 more
core
A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]
, 2012 Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro +6 more
core +3 more sources
Advanced oral drug delivery systems: Current challenges and emerging technologies
Acta Pharmaceutica Sinica BOral dosage is the most commonly used and preferred method of drug administration due to its several advantages, including non-invasiveness, patient adherence, and ease of use.
Satomi Onoue +2 more
doaj +1 more source
The Scientific World Journal, 2014 Nonionic surfactant vesicles (niosomes) were formulated with an aim of enhancing the oral bioavailability of tenofovir disoproxil fumarate (TDF), an anti-HIV drug.
Sunil Kamboj, Vipin Saini, Suman Bala
doaj +1 more source
Kaempferol-Phospholipid Complex: Formulation, and Evaluation of Improved Solubility, In Vivo Bioavailability, and Antioxidant Potential of Kaempferol [PDF]
, 2016 The current work describes the formulation and evaluation of a phospholipid complex of kaempferol toenhance the latter’s aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotectiveactivities, and oral bioavailability.
Anand, Sridhar +5 more
core +2 more sources
Drug Delivery, 2021 Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility.
Xinhui Du, Na Gao, Xiaoyong Song
doaj +1 more source
Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats
Acta Pharmaceutica, 2016 This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction.
Zhou Zhaoxiang +3 more
doaj +1 more source
Norfloxacin mixed solvency based solid dispersions: An in-vitro and in-vivo investigation
Journal of Taibah University for Science, 2017 Norfloxacin (NF) is a synthetic fluoro-quinolone molecule that is used for the treatment of urinary tract infections. However, due to its poor aqueous solubility, it has low oral bioavailability.
Ravindra Kamble +2 more
doaj +1 more source