Results 81 to 90 of about 162,747 (308)

Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique [PDF]

, 2016
Haiying Li,1 Tingting Pan,1 Ying Cui,1 Xiaxia Li,1 Jiefang Gao,1 Wenzhi Yang,1 Shigang Shen2 1Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, 2Key Laboratory of Analytical Science and Technology of Hebei Province,
Cui Y, Gao JF, Shen SG, Li HY, Li XX, Yang WZ, Pan TT   +6 more
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A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Formulation and Characterization of Eplerenone Nanoemulsion Liquisolids, An Oral Delivery System with Higher Release Rate and Improved Bioavailability

Pharmaceutics, 2019
Because Eplerenone (EPL) is a Biopharmaceutical Classification System (BCS) class-II drug and is prone to extensive liver degradation, it suffers from poor bioavailability after oral administration.
Ahmed Khames
doaj   +1 more source

Pharmacokinetics and enhanced oral bioavailability in beagle dogs of cyclosporine A encapsulated in glyceryl monooleate/poloxamer 407 cubic nanoparticles [PDF]

, 2009
Jie Lai1,2, Yi Lu1, Zongning Yin2, Fuqiang Hu3, Wei Wu11School of Pharmacy, Fudan University, Shanghai, China, 2West China School of Pharmacy, Sichuan University, Chengdu, China, 3School of Pharmacy, Zhejiang University, Hangzhou, ChinaAbstract: Efforts ...
Jie Lai, Zongning Yin, et al, Yi Lu
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Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver [PDF]

, 2001
Purpose: Although oral fluoropyrimidine prodrugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient.
Brown, G, McLelland, Heather R., Moyses, Chris, O'Byrne, K.J., Eatock, MM, Moyses, C, McLelland, H.R., Eatock, M.M., Carmichael, J., Eatock, Martin M., Steward, William P., O'Byrne, KJ, Clayton, KT, Brown, G., Sharma, Ricky A., Clayton, K.T., Brown, Gill, Twelves, Christopher J., O'Byrne, Kenneth J., Moyses, C., Carmichael, James, Carmichael, J, Steward, W.P., Twelves, C.J., Sharma, Ricky, McLelland, HR, Clayton, Kathryn T., Twelves, CJ, Sharma, R.A., Steward, WP   +29 more
core   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation [PDF]

, 2013
Ling Zhao,1,2 Yumeng Wei,1,2 Yu Huang,1 Bing He,2 Yang Zhou,1 Junjiang Fu31Department of Pharmaceutical Sciences, School of Pharmacy, Luzhou Medical College, Luzhou City, Sichuan Province, People's Republic of China; 2Drug and Functional Food ...
Zhao L, Huang Y, Fu J, Zhou Y, Wei Y, He B   +5 more
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Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption. [PDF]

, 2015
Oral absorption depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal absorption ...
Newby, Danielle, Ghafourian, Taravat, Freitas, Alex. A., Danielle Newby (1695076), Alex A Freitas (16236734), Taravat Ghafourian (4466557), Freitas, Alex A.   +6 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Formulation and processing technologies for enhanced oral bioavailability of poorly water soluble compounds [PDF]

, 2009
textDevelopments in high throughput screening and combinatorial chemistry have contributed to the unprecedented success of the pharmaceutical industry over the last twenty years, leading to a multitude of blockbuster compounds that revolutionized ...
DiNunzio, James Carlo
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