Results 71 to 80 of about 261,112 (210)
Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading. [PDF]
, 2017 Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor ...
Bogdanoff, Derek B +6 more
core +1 more source
Lactoferrin's anti-cancer properties. Safety, selectivity, and wide range of action [PDF]
, 2020 Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the ...
Bonaccorsi di Patti, M. C. +6 more
core +1 more source
Influence of hydroxychloroquine on the bioavailability of oral metoprolol [PDF]
British Journal of Clinical Pharmacology, 2000 Aims Hydroxychloroquine (HCQ) is used widely in the treatment of chronic inflammatory diseases such as rheumatoid arthritis. Since there is great interindividual variability in the pharmacokinetics of HCQ and chloroquine is a potent inhibitor of CYP2D6‐catalysed pathways in vitro, we wished to study the interaction of HCQ with ...
M, Somer +5 more
openaire +2 more sources
, 2003 Cadmium (Cd) is a well-known nephrotoxic environmental contaminant but there are indications that the developing nervous system might be even more sensitive to Cd than the kidneys in adults.
Eklund, Gunilla
core
Pharmaceutics, 2019 Because Eplerenone (EPL) is a Biopharmaceutical Classification System (BCS) class-II drug and is prone to extensive liver degradation, it suffers from poor bioavailability after oral administration.
Ahmed Khames
doaj +1 more source
Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs [PDF]
, 2018 The objective of this study was to investigate the impact of different hydrophobic ion pairs (HIP) on the oral bioavailability of the model drug octreotide in pigs.
Abdulkarim, Muthanna +7 more
core +2 more sources
Impact of Mucositis on Absorption and Systemic Drug Exposure of Isavuconazole [PDF]
, 2017 Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations.
Desai, Amit V +7 more
core +1 more source
Effect of probucol on the oral bioavailability of cyclosporine A
European Journal of Pharmaceutical Sciences, 2004 We have previously reported the reduction in oral bioavailability of cyclosporine A (CsA) by probucol, a lipid-lowering drug. To evaluate the mechanism, we examined the effect of probucol on the transport of CsA across Caco-2 cell monolayers, on the influence of CsA pharmacokinetics in rats, and on the change of ultraviolet-absorption spectrum of the ...
Koh-ichi, Sugimoto +6 more
openaire +2 more sources
, 2009 An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core
The pharmacokinetics of anthocyanins and their metabolites in humans [PDF]
, 2014 Background and Purpose: Anthocyanins are phytochemicals with reported vasoactive bioactivity. However, given their instability at neutral pH, they are presumed to undergo significant degradation and subsequent biotransformation.
Anupongsanugool +46 more
core +1 more source