Results 91 to 100 of about 1,626,235 (296)

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Enhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin

, 2018
Li Jun,1,2,* Yang Min,2,* Xu Wen-Rong11School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; 2Department of Intensive Care Unit, Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030,
Li J, Xu WR, Yang M
core  

MIL-100(Fe)-Enabled Oral Delivery of Syringic Acid with Enhanced Pharmacokinetics

Pharmaceutics
Background/Objectives: Plant-derived bioactive compounds like syringic acid, a phenolic acid from the shikimic acid pathway, have shown potential against chronic diseases, including diabetes, cardiovascular disorders, cancer, and cerebral ischemia ...
Joshua H. Santos, Hannah Jean Victoriano, Mary Sepulveda, Hung-En Liu, Shierrie Mae N. Valencia, Rikkamae Zinca Marie L. Walde, Emelda A. Ongo, Chia-Her Lin   +7 more
doaj   +1 more source

Bioavailability of low-dose oral etoposide.

, 1993
PURPOSE To determine the bioavailability of oral etoposide capsules administered at doses of 100 mg and 400 mg. PATIENTS AND METHODS The bioavailability of oral etoposide was determined by measuring the area under the etoposide plasma concentration ...
K R Hande, F A Greco, D H Johnson, J D Hainsworth, M G Krozely   +4 more
core   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

Advanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie, Jiahe Liu, Xiangyu Zhao, Siying Yang, Han Sun, Bingqian Jia, Xiaohong Ren, Xintao Chen, Lixin Sun, Li Wu, Caifen Wang, Jiwen Zhang   +11 more
wiley   +1 more source

Ibrutinib oral suspension bioavailability and compatibility for optimal enteral administration route

Therapeutic Advances in Hematology
Background: Ibrutinib is the only Bruton tyrosine kinase inhibitor (BTKi) with once-daily oral capsule, tablet, and oral suspension formulations approved in the United States across indications of chronic lymphocytic leukemia/small lymphocytic lymphoma ...
Jonas Paludo, Lisa Nodzon, Xavier Woot de Trixhe, Michelle Pacia, Heena Mavani, Harisha Atluri, Thomas J. Huemann, Jessica Shelly, Yemin Liu, Shayna Sarosiek   +9 more
doaj   +1 more source

Improved Oral Bioavailability Using a Solid Self-Microemulsifying Drug Delivery System Containing a Multicomponent Mixture Extracted from Salvia miltiorrhiza

Molecules, 2016
The active ingredients of salvia (dried root of Salvia miltiorrhiza) include both lipophilic (e.g., tanshinone IIA, tanshinone I, cryptotanshinone and dihydrotanshinone I) and hydrophilic (e.g., danshensu and salvianolic acid B) constituents.
Xiaolin Bi, Xuan Liu, Liuqing Di, Qiang Zu   +3 more
doaj   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Preparation and in vivo evaluation of a gel-based nasal delivery system for risperidone

Acta Pharmaceutica, 2016
The aim of this study was to prepare a nasal gel of risperidone and to investigate the pharmacokinetics and relative bioavailability of the drug in rats.
Gu Fugen, Ma Weina, Meng Gendalai, Wu Chunzhi, Wang Yi   +4 more
doaj   +1 more source

Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption. [PDF]

, 2015
Oral absorption depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal absorption ...
Newby, Danielle, Ghafourian, Taravat, Freitas, Alex. A., Danielle Newby (1695076), Alex A Freitas (16236734), Taravat Ghafourian (4466557), Freitas, Alex A.   +6 more
core   +1 more source