Results 91 to 100 of about 261,112 (210)

Preparation and in vivo evaluation of a gel-based nasal delivery system for risperidone

Acta Pharmaceutica, 2016
The aim of this study was to prepare a nasal gel of risperidone and to investigate the pharmacokinetics and relative bioavailability of the drug in rats.
Gu Fugen, Ma Weina, Meng Gendalai, Wu Chunzhi, Wang Yi   +4 more
doaj   +1 more source

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

Pharmaceutics, 2018
Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders. Until now, little is known about its pharmacokinetic profile. Our
Eman A. Alraddadi, Ryan Lillico, Jonathan L. Vennerstrom, Ted M. Lakowski, Donald W. Miller   +4 more
doaj   +1 more source

Bioaccessibility and human health risk : chromium in Glasgow [PDF]

, 2006
The assessment of risk to human health from contaminated land is based on a comparison of predicted human exposure to a contaminant with a Health Criteria Value (HCV) that represents an exposure below which there is thought to be little or no risk to ...
Bewley, RJ.F., Broadway, A., Cave, M.R., Farmer, J.G., Fordyce, F.M., Ngwenya, B.T.   +5 more
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Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]

, 2013
In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Klein, Sandra, Taupitz, Thomas
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Development and evaluation of a novel nebulized dihydromyricetin formulation: enhanced pulmonary delivery and pharmacokinetic properties

Respiratory Research
Background Respiratory diseases are a major global health burden, and inhalation therapy offers efficient pulmonary targeting and therapeutic effectiveness.
Kunyan Xu, Jianing Yang, Meng Yan, Dan Li, Wenli Du, Jing Bai, Bai Xiang   +6 more
doaj   +1 more source

Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]

, 2019
The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B., Dave, Vivek S, Patil, Arun T., Pethe, Anil M., Raut, Nishikant, Telange, Darshan R., Umekar, Milind J.   +6 more
core   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

Impact of oil type on the development and oral bioavailability of self-nanoemulsifying drug delivery systems containing simvastatin

Scientific Reports
The aim of this work is to develop and evaluate self-nanoemulsifying drug delivery systems (SNEDDS) containing simvastatin to increase its oral bioavailability.
Aya Hamdy, Mahmoud El-Badry, M. Fathy, Ahmed M. El-Sayed   +3 more
doaj   +1 more source

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system

International Journal of Nanomedicine, 2012
Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaBackground: Indirubin, isolated from the leaves of the Chinese herb Isatis
Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP
doaj  

Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. [PDF]

, 2019
PURPOSE:The purpose of this study was to determine the impact of food on gastric pH and the ability of over the counter betaine hydrochloride (BHCl) acid to reacidify gastric pH after food-induced elevations in gastric pH.
Benet, Leslie Z, Frassetto, Lynda A, Surofchy, Dalga D   +2 more
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