Results 101 to 110 of about 162,747 (308)

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers [PDF]

, 2017
Cihui Tian,1 Sajid Asghar,2 Yifan Wu,1 Zhipeng Chen,3 Xin Jin,1 Lining Yin,1 Lin Huang,1 Qineng Ping,1 Yanyu Xiao1 1Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China; 2Faculty of ...
Jin X, Asghar S, Chen Z, Xiao Y, Tian C, Huang L, Yin L, Ping Q, Wu Y   +8 more
core  

Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats: comparison with gentiopicroside alone [PDF]

, 2007
The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentian plant species, from orally administered decoctions of Gentianae (DG), or in combination with other plants in the prescription of Longdan Xiegan Tang ...
Cheng, X.M., Wang, C.-H., Branford-White, C.J., White, K.N., Wang, Z., Bligh, S.W.A.   +5 more
core   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach [PDF]

, 2018
Jagruti B Prajapati, Sneha D Verma, Amit A Patel Department of Ppharmaceutics and Ppharmaceutical Technology, Rramanbhai Patel College of Ppharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Agomelatine (AGM) is a ...
Prajapati JB, Verma SD, Patel AA
core  

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers [PDF]

, 2015
Jun Zhou,1,2 Daxin Zhou3 1Department of Medicine, Clinical Medical College of Soochow University, 2Department of Medicine, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 3Department of Cardiovascular Medicine, Zhongshan Hospital ...
Zhou DX, Zhou J
core  

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Impact of water hardness on oxytetracycline oral bioavailability in fed and fasted piglets

Veterinary Medicine and Science, 2019
Water hardness is a critical factor that affects oxytetracycline dissolution by chelation with cations. These interactions may lead to impaired dosing and consequently decrease absorption.
Julieta M. Decundo, Susana N. Diéguez, Guadalupe Martínez, Agustina Romanelli, María B. Fernández Paggi, Denisa S. Pérez Gaudio, Fabián A. Amanto, Alejandro L. Soraci   +7 more
doaj   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Fructose intestinal, hepatic, and oral bioavailability. [PDF]

, 2018
Fa x Fg = intestinal availability or fructose absorption. Fh = hepatic availability. F = oral bioavailability.
MyPhuong T. Le (103457), Melanie S. Joy (792024), Zhiying You (59104), Christopher J. Rivard (119936), Leah R. Villegas (5946410), Brandi Hunter (119941), Carlos Roncal (5946413)   +6 more
core   +1 more source