Results 21 to 30 of about 1,626,235 (296)

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates

Asian Journal of Pharmaceutical Sciences, 2019
Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs.
Yixin Sun, Dongyang Zhao, Gang Wang, Qikun Jiang, Mengran Guo, Qiming Kan, Zhonggui He, Jin Sun   +7 more
doaj   +1 more source

Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery

Pharmaceutics, 2020
Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility in improving oral drug bioavailability ...
Greta Carobolante, Julia Mantaj, Enrico Ferrari, Driton Vllasaliu   +3 more
doaj   +1 more source

Folate bioavailability [PDF]

, 2009
An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core   +1 more source

Oral Bioavailability Enhancement of Raloxifene with Nanostructured Lipid Carriers

Nanomaterials, 2020
Raloxifene hydrochloride (RLX) shows poor bioavailability (90%). The objective of this study was to develop nanostructured lipid carriers (NLCs) for RLX to enhance its bioavailability.
Aditya Murthy, Punna Rao Ravi, Himanshu Kathuria, Shrinivas Malekar   +3 more
doaj   +1 more source

Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults [PDF]

Exploration of Drug Science
Aim: The objective of this study was to evaluate the predictive performance of a proposed method to predict absolute bioavailability of medicines in children (infants to adolescents).
Iftekhar Mahmood
doaj   +1 more source

Antituberculosis Macozinone Extended-Release Tablets To Enhance Bioavailability: a Pilot Pharmacokinetic Study in Beagle Dogs

Microbiology Spectrum, 2023
Macozinone (MCZ; PBTZ169) is a first-in-class antituberculosis clinical-stage benzothiazinone-based drug candidate. Although its efficacy and safety have been strongly proven in several preclinical and clinical studies, the physicochemical and ...
Angela Koryakova, Victoria Shcherbakova, Olga Riabova, Yurii Kazaishvili, Roman Bolgarin, Vadim Makarov   +5 more
doaj   +1 more source

Recent advances in improving oral drug bioavailability by cocrystals [PDF]

BioImpacts, 2018
Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami, Mohammadreza Siahi-Shadbad, Khosro Adibkia, Mohammad Barzegar-Jalali   +3 more
doaj   +1 more source

Influence of chitosan coating on the oral bioavailability of gold nanoparticles in rats

Saudi Pharmaceutical Journal, 2019
Gold nanoparticles are one of the most extensively investigated metallic nanoparticles for several applications. It is less toxic than other metallic nanolattices.
Ahmed Alalaiwe, Paul Carpinone, Saad Alshahrani, Bader Alsulays, Mohammed Ansari, Mohammed Anwer, Sultan Alshehri, Abdullah Alshetaili   +7 more
doaj   +1 more source

The Effect of Chemical Modifications of Chitosan on Intestinal Permeability and Oral Bioavailability of Carbamoylphosphonate JS403

, 2020
Art. 392, 8 S.JS403, Carbamoylphosphonate molecule, is a promising drug candidate with anti-metastatic activity. The polarityand water solubility of JS403 evolve from the phosphonate moiety that is ionized at physiologic pH.
Reich, Reuven, Bitton-Dotan, Reut, Tsuriel, Marina, Storsberg, Joachim, Hoffman, Amnon, Tulichala, RN Prasad, Bohrisch, Jörg, Breuer, Eli, Schmidt, Christian   +8 more
core   +1 more source

Solubilization of Paclitaxel with Natural Compound Rubusoside toward Improving Oral Bioavailability in a Rodent Model

Pharmaceutics
Paclitaxel, which features low water solubility and permeability, is an efflux pump substrate. The current paclitaxel drugs are given intravenously after resolving the solubility issue.
Jian Zhang, Jicheng Shu, Rhett W. Stout, Paul S. Russo, Zhijun Liu   +4 more
doaj   +1 more source