Results 21 to 30 of about 162,747 (308)
Absolute oral bioavailability of ciprofloxacin [PDF]
Antimicrobial Agents and Chemotherapy, 1986 We evaluated the absolute bioavailability of ciprofloxacin, a new quinoline carboxylic acid, in 12 healthy male volunteers. Doses of 200 mg were given to each of the volunteers in a randomized, crossover manner 1 week apart orally and as a 10-min intravenous infusion.
G L, Drusano +5 more
openaire +2 more sources
Oral diacetylmorphine (heroin) yields greater morphine bioavailability than oral morphine: bioavailability related to dosage and prior opioid exposure [PDF]
, 2008 AIMS: In the Swiss heroin substitution trials, patients are treated with self-administered diacetylmorphine (heroin). Intravenous administration is not possible in patients that have venosclerosis.
Eich-Höchli, D +9 more
core +1 more source
Pharmaceutics, 2020 Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility in improving oral drug bioavailability ...
Greta Carobolante +3 more
doaj +1 more source
Pharmaceuticals, 2022 Silymarin, a phyto-constituent derived from the plant Silybum marianum, has been widely acknowledged for its hepatoprotective activities. Nevertheless, its clinical utility is adversely hampered by its poor water-solubility and its limited oral ...
Ravi Gundadka Shriram +6 more
doaj +1 more source
A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
Asian Journal of Pharmaceutical Sciences, 2019 Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs.
Yixin Sun +7 more
doaj +1 more source
Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults [PDF]
Exploration of Drug ScienceAim: The objective of this study was to evaluate the predictive performance of a proposed method to predict absolute bioavailability of medicines in children (infants to adolescents).
Iftekhar Mahmood
doaj +1 more source
Oral Bioavailability Enhancement of Raloxifene with Nanostructured Lipid Carriers
Nanomaterials, 2020 Raloxifene hydrochloride (RLX) shows poor bioavailability (90%). The objective of this study was to develop nanostructured lipid carriers (NLCs) for RLX to enhance its bioavailability.
Aditya Murthy +3 more
doaj +1 more source
An Orally Bioavailable (Mice) Prodrug of Glutathione [PDF]
Antioxidants, 2021 Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH) --the “Master Antioxidant”, was found to be orally bioavailable in mice, and protected against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, this suggests a wide range of applicability for CySSG.
Herbert T. Nagasawa +3 more
openaire +4 more sources
Microbiology Spectrum, 2023 Macozinone (MCZ; PBTZ169) is a first-in-class antituberculosis clinical-stage benzothiazinone-based drug candidate. Although its efficacy and safety have been strongly proven in several preclinical and clinical studies, the physicochemical and ...
Angela Koryakova +5 more
doaj +1 more source
Recent advances in improving oral drug bioavailability by cocrystals [PDF]
BioImpacts, 2018 Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami +3 more
doaj +1 more source