Results 101 to 110 of about 45,385 (279)

Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection

, 2020
Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on this solubilization interplay using proton nuclear magnetic resonance ...
Pöppler, A., Galli, Bruno, Meinel, Lorenz, Harlacher, C., Meinel, L., Schlauersbach, Jonas, Lenz, B., Vemulapalli, S., Vemulapalli, Sahithya P. B., Vemulapalli, Sahithya P B, Hanio, Simon, Hanio, S., Vemulapalli, Sahithya P.B., Lenz, Bettina, Pöppler, Ann-Christin, Griesinger, C. ; https://orcid.org/, Vemulapalli, Sahithya, Schlauersbach, J., Galli, B., Harlacher, Cornelius, Griesinger, Christian   +20 more
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine) [PDF]

, 2007
Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica.
Yousef Javadzadeh, Jafari-Navimipour, Baharak, Javadzadeh, Yousef, Yousef Javadzadeh (16203113), Baharak Jafari-Navimipour (16203116), Ali Nokhodchi, Baharak Jafari-Navimipour, Nokhodchi, Ali, Ali Nokhodchi (4465915)   +8 more
core   +1 more source

Chiral of D-type mesoporous silica deliver anti-inflammatory drug with double synergism

Materials Today Advances
Chiral drug delivery systems have gained great attention in novel drug delivery applications. To explore their exceptional functions, a series of chiral mesoporous silica xerogel (L-SX, D-SX) was constructed using biomimetic method and another series of ...
Xue Yan, Lu Wang, Zhixiao Zhang, Xianbao Shi, Guowei Li   +4 more
doaj   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Enhancement of the dissolution rates of poorly water-soluble drugs by water-soluble gelatin.

Chemical and Pharmaceutical Bulletin, 1989
The dissolution behavior of several acidic and basic drugs from kneaded mixtures with water-soluble gelatin have been studied in comparison with that of the drug alone. The results revealed a significant increase of dissolution rate of drugs from kneaded mixtures.
IMAI, Teruko, NISHIYAMA, Tetsuyuki, UENO, Masao, OTAGIRI, Masaki   +3 more
openaire   +3 more sources

Biodegradable self-assembling PEG-copolymer as vehicle for poorly water-soluble drugs.

, 2004
PURPOSE: To develop self-assembling systems increasing the solubility of poorly water-soluble drugs. METHODS: Low molecular weight liquid biodegradable copolymers were synthesized by ring-opening polymerization using caprolactone (CAP) and ...
Brewster, Marcus, Leroy, Daniel, Rosenblatt, Joel, Dinguizli, Mustapha, Borgia, Maureen, Matalenas, Tom, Préat, Véronique, Rouxhet, Laurence, Twaddle, Patricia, Arnold, Steve, Ould-Ouali, Louisa, Nathan, Aruna, Ariën, Albertina   +12 more
core   +1 more source

Spontaneous Helical Alignment of Smooth Muscle Cells to Form a Medial Layer for Engineered Microvasculature

Advanced Healthcare Materials, EarlyView.
Spontaneous helical alignment of smooth muscle cells is induced within resistance‐vessel‐sized channels patterned within a hydrogel. The extent of the cells’ orientation angle is dependent on the presence and composition of ECM proteins lining the channel wall and cell seeding density.
Victoria D. Vest, Katherine J. Young, Isabella K. Holtz, Mark Mc Veigh, James D. West, Leon M. Bellan   +5 more
wiley   +1 more source

Polymer strip films for delivery of poorly water-soluble drugs

, 2015
While polymer strip films have garnered significant attention for their patient compliance and cost-effective scale-up, recent studies have shown that they are also an ideal platform for poorly water-soluble drug delivery. This article offers a review of
Krull, Scott M., Bilgili, Ecevit, Li, Meng, Davé, Rajesh N.   +3 more
core