Results 61 to 70 of about 7,280,281 (268)
“Examples of Drug Delivery Systems for Delivery of Certain Poorly Water-Soluble Drugs” [PDF]
Records of Pharmaceutical & Biomedical SciencesThe Biopharmaceutical Classification System (BSC) classifies the drugs according to their solubility in water. Drugs that have poor solubility in water fall under Classes II and IV.
rasha Zidan
doaj +1 more source
Enhancing delivery of poorly water-soluble drugs by innovative amorphous solid dispersions [PDF]
, 2022 Poorly water-soluble drugs continue to dominate today’s drug development pipelines, and thus a multitude of technologies and solubility-enhancing methodologies have been commercialized to address this issue. One-such methodology to enhance the solubility
Jermain, Scott Victor
core +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2010 In titrimetric analysis costlier organic solvents are more often employed to solubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of such solvents.
R K Maheshwari, Shruti Moondra
doaj +2 more sources
Scientifica, 2016 Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral ...
Mayank Sharma +2 more
doaj +1 more source
, 2010 A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and ...
Hiren Bechra +3 more
core +1 more source
Lipid-based systems as promising approach for enhancing the bioavailability of poorly water-soluble drugs [PDF]
, 2013 Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization ...
ČERPNJAK, KATJA +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs
Brazilian Archives of Biology and Technology, 2012 In this study, fluid bed granulation was applied to improve the dissolution of nimodipine and spironolactone, two very poorly water-soluble drugs. Granules were obtained with different amounts of sodium dodecyl sulfate and croscarmellose sodium and then ...
Andrea Ikeda Takahashi +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco +8 more
wiley +1 more source