Results 41 to 50 of about 7,280,281 (268)
ADMET and DMPK, 2019 The purpose of the present study was to harmonize the protocol of equilibrium solubility measurements for poorly water-soluble drugs to lower inter-laboratory variance.
Asami Ono +15 more
doaj +1 more source
Improving “gut feelings” for poorly water-soluble drugs
, 2018 A nanocarrier system self-assembled in the intestine significantly improves oral availability of poorly water-soluble drugs.
Keyue Shen
core +1 more source
VARIOUS TECHNIQUES ENHANCING BIOAVAILABILTY OF POORLY WATER SOLUBLE DRUGS [PDF]
, 2013 A drug administered in solution form immediately available for absorption and efficiently absorbed than the same amount of drug administered in a tablet or capsule form.
Nirmala, Nirmala +2 more
core +1 more source
In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs
European Journal of Pharmaceutical Sciences, 2000 Although several routes of administration can be considered for new drug entities, the most popular remains the oral route. To predict the in vivo performance of a drug after oral administration from in vivo data, it is essential that the limiting factor to absorption can be modelled in vitro.
Dressman, J.B., Reppas, C.
openaire +3 more sources
The application of microwave formulation and isothermal titration calorimetry for pharmaceutical compounds [PDF]
Solid dispersions are commonly used to overcome bioavailability issues of poorly water soluble drugs. Various preparation methods along with carrier systems have been used to develop solid dispersions.
Hussain, Talib
core +2 more sources
Solubilization of Poorly Water-soluble Drugs with Amphiphilic Phospholipid Polymers
YAKUGAKU ZASSHI, 2023 Most drug candidates developed in recent years are poorly water-soluble, which is a key challenge in pharmaceutical science. Various solubilization methods have been investigated thus far, most of which require solubilizers that provide a local hydrophobic environment wherein a drug can dissolve or induce interactions with drug molecules.
Kensuke, Yoshie, Kazuhiko, Ishihara
openaire +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Development of Liquisolid Technology to Overcome Dissolution/Absorption Limitations of Oral Drugs
Pharmaceutical FrontsIncreasing influx of poorly water-soluble drugs poses a significant challenge to oral drug delivery. Conventional solubilization techniques such as solid dispersion and cyclodextrin inclusion, while capable of improving drug dissolution, suffer from a ...
Huan Wang, Xingwang Zhang
doaj +1 more source
Insoluble drug delivery strategies: review of recent advances and business prospects
Acta Pharmaceutica Sinica B, 2015 The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
Sandeep Kalepu, Vijaykumar Nekkanti
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source