Results 31 to 40 of about 50,651 (209)

Nanosuspension: An approach to enhance solubility of drugs

Journal of Advanced Pharmaceutical Technology & Research, 2011
One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media ...
Vishal R Patel, Y K Agrawal
doaj   +1 more source

Development and Characterization of the Solvent-Assisted Active Loading Technology (SALT) for Liposomal Loading of Poorly Water-Soluble Compounds

Pharmaceutics, 2019
A large proportion of pharmaceutical compounds exhibit poor water solubility, impacting their delivery. These compounds can be passively encapsulated in the lipid bilayer of liposomes to improve their water solubility, but the loading capacity and ...
Griffin Pauli, Wei-Lun Tang, Shyh-Dar Li
doaj   +1 more source

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

Frontiers in Bioengineering and Biotechnology, 2023
The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology.
Ruiliang Ge, Yuexin Ji, Yanfei Ding, Chang Huang, Hua He, Deng-Guang Yu   +5 more
doaj   +1 more source

Unravelling the Miscibility of Poly(2-oxazoline)s: A Novel Polymer Class for the Formulation of Amorphous Solid Dispersions

Molecules, 2020
Water-soluble polymers are still the most popular carrier for the preparation of amorphous solid dispersions (ASDs). The advantage of this type of carrier is the fast drug release upon dissolution of the water-soluble polymer and thus the initial high ...
Melissa Everaerts, Ali Tigrine, Victor R. de la Rosa, Richard Hoogenboom, Peter Adriaensens, Christian Clasen, Guy Van den Mooter   +6 more
doaj   +1 more source

Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs

Molecules, 2022
At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions,
Arvind Sharma, Kanika Arora, Harapriya Mohapatra, Rakesh K. Sindhu, Madalin Bulzan, Simona Cavalu, Gulsheen Paneshar, Hosam O. Elansary, Ahmed M. El-Sabrout, Eman A. Mahmoud, Abdullah Alaklabi   +10 more
doaj   +1 more source

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

Molecules, 2016
The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative ...
Kyeong-Ok Choi, Jaehyeog Choe, Seokjin Suh, Sanghoon Ko   +3 more
doaj   +1 more source

Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach

Journal of Pharmacy and Bioallied Sciences, 2012
The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process.
Divyesh Thakar, Praful Bharadia, Vikram Pandya   +2 more
doaj   +1 more source

Improved oral bioavailability of poorly water-soluble vorinostat by self-microemulsifying drug delivery system

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Vorinostat is a histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) with anticancer properties. However, it is plagued by low water solubility, low permeability (BCS class IV drug), and suboptimal pharmacokinetics. The purpose
Ashok Kumar Janakiraman, Tahani Islam, Kai Bin Liew, Manogaran Elumalai, J. C. Hanish Singh   +4 more
doaj   +1 more source

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

Asian Journal of Pharmaceutical Sciences, 2014
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.
Prakash Khadka, Jieun Ro, Hyeongmin Kim, Iksoo Kim, Jeong Tae Kim, Hyunil Kim, Jae Min Cho, Gyiae Yun, Jaehwi Lee   +8 more
doaj   +1 more source

Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs

Pharmaceuticals, 2022
The processes of solubilization and controlled release of drugs that are poorly soluble in water are highly relevant in drug preformulation studies in pharmaceutical development [...]
M. A. Peña
doaj   +1 more source