Results 31 to 40 of about 7,969,000 (286)
Molecules, 2021 Some medicines are poorly soluble in water. For tube feeding and parenteral administration, liquid formulations are required. The discovery of natural deep eutectic solvents (NADES) opened the way to potential applications for liquid drug formulations ...
Natali Rianika Mustafa +4 more
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Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2020 Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid ...
Thao T. D. Tran, Phuong H. L. Tran
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Solubility Enhancement of Poorly Water Soluble Drug
, 2023 The Biopharmaceutical Classification System includes solubility as one of its core criteria, and dissolution rate is the most crucial variable affecting a drug's bioavailability. A weakly water-soluble medication is defined as a substance with a solubility of less than 1 part per 10,000 parts of water.
Madkaikar S.A., Shukla U.D.
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The application of microwave formulation and isothermal titration calorimetry for pharmaceutical compounds [PDF]
Solid dispersions are commonly used to overcome bioavailability issues of poorly water soluble drugs. Various preparation methods along with carrier systems have been used to develop solid dispersions.
Hussain, Talib
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Nanosuspension: An emerging trend to improve solubility of poorly water soluble drugs [PDF]
, 2019 There are various parameters like solubility, stability, compatibility, excipient, and photostability which affects formulation of drugs, but solubility plays an important role for drug formulation. Most of newly discovered drugs are poorly water soluble.
Vedaga, S. B. +2 more
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Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
Frontiers in Bioengineering and Biotechnology, 2023 The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology.
Ruiliang Ge +5 more
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Insights into the biopharmaceutical behavior of oral lipid-based formulations using advanced analytical techniques and mathematical modeling [PDF]
, 2014 Lipid-based formulations (LBFs) are effective means for the oral delivery of poorly water-soluble compounds. The drug is already solubilized in the formulation and, thus, the critical dissolution step is circumvented. However, the oral bioavailability is
Stillhart, Cordula Edith
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Pharmaceutics, 2019 A large proportion of pharmaceutical compounds exhibit poor water solubility, impacting their delivery. These compounds can be passively encapsulated in the lipid bilayer of liposomes to improve their water solubility, but the loading capacity and ...
Griffin Pauli, Wei-Lun Tang, Shyh-Dar Li
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Molecules, 2020 Water-soluble polymers are still the most popular carrier for the preparation of amorphous solid dispersions (ASDs). The advantage of this type of carrier is the fast drug release upon dissolution of the water-soluble polymer and thus the initial high ...
Melissa Everaerts +6 more
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Melt-electrospinning as a method to improve the dissolution and physical stability of a poorly water-soluble drug [PDF]
, 2018 The present study introduces a modified melt-electrospinning (MES) method for fabricating the melt-electrospun fibers (MSFs) of a poorly water-soluble drug and carrier polymer. The MES of poorly water-soluble model drug indomethacin (IND) and hydrophilic
Lust, Andres +19 more
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