Results 31 to 40 of about 145,891 (201)
Lipid nanoparticles for the delivery of poorly water-soluble drugs [PDF]
Journal of Pharmacy and Pharmacology, 2010 Abstract Objectives This review discusses important aspects of lipid nanoparticles such as colloidal lipid emulsions and, in particular, solid lipid nanoparticles as carrier systems for poorly water-soluble drugs, with a main focus on the parenteral and peroral use of these carriers.
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Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2020 Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid ...
Thao T. D. Tran, Phuong H. L. Tran
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Hydrophilic Matrices for Oral Control Drug Delivery [PDF]
, 2015 Oral controlled drug delivery has gathered tremendous attention over the years due to its many advantages over conventional dosage forms. Polymer-based matrices have become an integral part of the pharmaceutical industry. Hydrophilic matrices are capable
Conway, Barbara R, Ghori, Muhammad U.
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Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
Frontiers in Bioengineering and Biotechnology, 2023 The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology.
Ruiliang Ge +5 more
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Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]
, 2019 Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair +57 more
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Pharmaceutics, 2019 A large proportion of pharmaceutical compounds exhibit poor water solubility, impacting their delivery. These compounds can be passively encapsulated in the lipid bilayer of liposomes to improve their water solubility, but the loading capacity and ...
Griffin Pauli, Wei-Lun Tang, Shyh-Dar Li
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Molecules, 2020 Water-soluble polymers are still the most popular carrier for the preparation of amorphous solid dispersions (ASDs). The advantage of this type of carrier is the fast drug release upon dissolution of the water-soluble polymer and thus the initial high ...
Melissa Everaerts +6 more
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Molecules, 2022 At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions,
Arvind Sharma +10 more
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Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs [PDF]
, 2019 Despite the fact that solid dispersions are gaining momentum, the number of polymers that have been used as a carrier during the past 50 years is rather limited.
Boel, Eline +5 more
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Solubility Enhancement of Poorly Water Soluble Drug
, 2023 The Biopharmaceutical Classification System includes solubility as one of its core criteria, and dissolution rate is the most crucial variable affecting a drug's bioavailability. A weakly water-soluble medication is defined as a substance with a solubility of less than 1 part per 10,000 parts of water.
Madkaikar S.A., Shukla U.D.
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