Results 51 to 60 of about 145,891 (201)

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

Asian Journal of Pharmaceutical Sciences, 2014
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.
Prakash Khadka, Jieun Ro, Hyeongmin Kim, Iksoo Kim, Jeong Tae Kim, Hyunil Kim, Jae Min Cho, Gyiae Yun, Jaehwi Lee   +8 more
doaj   +1 more source

Processing-Induced Disorder in Pharmaceutical Materials [PDF]

, 2016
This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally.
Al-Obaidi, Alkhatib, Alonzo, Bahl, Balani, Breitenbach, Brough, Brown, Cal, Cerea, Chakraborty, Chattoraj, Chieng, Clark, Cordeiro, Cui, De Beer, Descamps, DiNunzio, Dinunzio, El-Badry, Elamin, Felton, Feng, Forster, Gazzaniga, Graeser, Guns, Gupta, He, Hu, Hu, Janssens, Kang, Karmwar, Ke, Keen, Khan, Kim, Koivisto, Lai, Laitinen, Laitinen, Lang, Lauer, Luisi, Luo, Löbmann, Löbmann, Nagy, Ng, Norrman, Otte, Otte, Passerini, Patterson, Porter, Qi, Qi, Qi, Qi, Repka, Riippi, Saerens, Sammoura, Santivarangkna, Sauer, Sauer, Sill, Sollohub, Tang, Trasi, Trasi, Van den Brande, Van Eerdenbrugh, Van Eerdenbrughand, Van Melkebeke, Vehring, Weatherley, Weuts, Willart, Willart, Willart, Williams, Windbergs, Windbergs, Wojnarowska, Yang, Zamani, Zema   +89 more
core   +1 more source

Solubilization of Poorly Water-soluble Drugs with Amphiphilic Phospholipid Polymers

YAKUGAKU ZASSHI, 2023
Most drug candidates developed in recent years are poorly water-soluble, which is a key challenge in pharmaceutical science. Various solubilization methods have been investigated thus far, most of which require solubilizers that provide a local hydrophobic environment wherein a drug can dissolve or induce interactions with drug molecules.
Kensuke, Yoshie, Kazuhiko, Ishihara
openaire   +2 more sources

A novel method for quantitative determination of aceclofenac in bulk drug and tablets using sodium salicylate as a hydrotropic solubilizing agent

Journal of Advanced Pharmaceutical Technology & Research, 2010
In titrimetric analysis costlier organic solvents are more often employed to solubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of such solvents.
R K Maheshwari, Shruti Moondra
doaj   +2 more sources

A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution

Asian Journal of Pharmaceutical Sciences, 2015
To enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated.
Pornsak Sriamornsak, Sontaya Limmatvapirat, Suchada Piriyaprasarth, Punyanutch Mansukmanee, Zongkang Huang   +4 more
doaj   +1 more source

The enhancement of the aqueous solubility of ritonavir via formulation of a drug-phospholipid complex [PDF]

, 2015
Objective: To evaluate the enhancement of aqueous solubility of a poorly water soluble drug ritonavir by forming its complex with a phospholipid (Phospholipon®90H)
Bernardez, M., Dave, Vivek S, Dhore, Pradip, Diware, R. G., Haware, Rahul V., Raut, Nishikant, Saoji, Suprit   +6 more
core   +1 more source

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]

, 2015
The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco, COVIELLO, Tommasina, DI MEO, Chiara, MATRICARDI, PIETRO, MONTANARI, ELITA   +4 more
core   +1 more source

Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase [PDF]

Pharmaciana, 2017
Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability.
Sani Ega Priani, Nurrayyan, Fitrianti Darusman   +2 more
doaj   +1 more source

Solubility and solution thermodynamics of raloxifene hydrochloride in various (DMSO + water) compositions

Alexandria Engineering Journal, 2022
The solubility of the poorly soluble drug raloxifene hydrochloride (3) in binary {dimethyl sulfoxide (DMSO) (1) + water (2)} mixtures have been recorded at several temperatures under atmospheric pressure.
Mohammad Alyamani, Sultan Alshehri, Prawez Alam, Shahid Ud Din Wani, Mohammed M. Ghoneim, Faiyaz Shakeel   +5 more
doaj   +1 more source

Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique

Journal of Pharmacy and Bioallied Sciences, 2012
The present study was aimed to increase the solubility of the poorly water soluble drug benfotiamine using hydrophilic polymers (PVP K-30 and HPMC E4). Solid dispersions were prepared by kneading method.
S M Patel, R P Patel, B G Prajapati
doaj   +1 more source