Results 51 to 60 of about 7,969,000 (286)

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

Asian Journal of Pharmaceutical Sciences, 2014
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.
Prakash Khadka, Jieun Ro, Hyeongmin Kim, Iksoo Kim, Jeong Tae Kim, Hyunil Kim, Jae Min Cho, Gyiae Yun, Jaehwi Lee   +8 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Risk Assessment of Factors Affecting Physical and Chemical Stability of Solid Dispersions of Poorly-Soluble Drugs

مجلة بغداد للعلوم
Solid dispersions are one of the most promising strategies to overcome the poor aqueous solubility of some drug substances. However, the physical and chemical instability of solid dispersions has limited their use. The purpose of this study was to assess
Iyad H Allous, Shuaib I Alahmad, Youssef S Alahmad, Mirvat A Mourad   +3 more
doaj   +1 more source

“Examples of Drug Delivery Systems for Delivery of Certain Poorly Water-Soluble Drugs” [PDF]

Records of Pharmaceutical & Biomedical Sciences
The Biopharmaceutical Classification System (BSC) classifies the drugs according to their solubility in water. Drugs that have poor solubility in water fall under Classes II and IV.
rasha Zidan
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Formulation of thermoresponsive and buccal adhesive in situ gel for treatment of oral thrush containing poorly water soluble drug bifonazole

Journal of Pharmacy and Bioallied Sciences, 2012
The aim of the present work is to formulate and evaluate in situ oral topical gels of poorly water soluble drug Bifonazole based on temperature induced systems for the treatment of oral candidiasis.
Dimendra Patel, Dipti Patel, Jatin Prajapati, Umang Patel, Vijay Patel   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase [PDF]

Pharmaciana, 2017
Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability.
Sani Ega Priani, Nurrayyan, Fitrianti Darusman   +2 more
doaj   +1 more source

NANOSUSPENSION TECHNOLOGY: A INNOVATIVE SLANT FOR DRUG DELIVERY SYSTEM AND PERMEABILITY ENHANCER FOR POORLY WATER SOLUBLE DRUGS [PDF]

, 2015
Nanosuspension contains submicron colloidal dispersion of pharmaceutical active ingredient particles in a liquid phase stabilized by surfactants. The poor water solubility of drugs is major problem for drug formulation.
Patel, Bhavesh, Shah, Dhiren P., Shah, Chainesh   +2 more
core   +1 more source