Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization
Asian Journal of Pharmaceutical Sciences, 2015 The objective of the present study was to alter the crystal habit of itraconazole (ITZ) by cooling and anti-solvent crystallization and characterize its properties.
Pornsak Sriamornsak +1 more
doaj +1 more source
Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation [PDF]
, 2013 In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer.
Boisen, Anja +8 more
core
Drug nanoparticles by emulsion-freeze-drying via the employment of branched block copolymer nanoparticles [PDF]
, 2016 A large percentage of drug compounds exhibit low water solubility and hence low bioavailability and therapeutic efficacy. This may be addressed by preparation of drug nanoparticles, leading to enhanced dissolution rate and direct use for treatment ...
He, Tao +5 more
core +1 more source
Solubilization techniques used for poorly water-soluble drugs
Acta Pharmaceutica Sinica BAbout 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application.
Bing Xie +4 more
openaire +2 more sources
A dataset of formulation compositions for self-emulsifying drug delivery systems
Scientific Data, 2023 Self-emulsifying drug delivery systems (SEDDS) are a well-established formulation strategy for improving the oral bioavailability of poorly water-soluble drugs.
Jonathan Zaslavsky, Christine Allen
doaj +1 more source
Confined crystallization of fenofibrate in nanoporous silica [PDF]
, 2015 Producing stable nanocrystals confined to porous excipient media is a desirable way to increase the dissolution rate and improve the bioavailability of poorly water soluble pharmaceuticals.
Dwyer, Leia Mary +4 more
core +1 more source
Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]
, 2020 The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham +3 more
core +1 more source
Advances in Polymer Technology, 2020 Solid dispersion (SD) is the effective approach to improve the dissolution rate and bioavailability of class II drugs with low water solubility and high tissue permeability in the Biopharmaceutics Classification System.
Qingyun Zeng +6 more
doaj +1 more source
Pharmaceutics, 2019 The crystal changes and salt formation of poorly water-soluble telmisartan (TEL) in various solvents were investigated for enhanced solubility, stability and crystallinity. Polymorphic behaviors of TEL were characterized by dispersing in distilled water,
Chulhun Park +9 more
doaj +1 more source
Chitosan-g-oligo(epsilon-caprolactone) polymeric micelles: microwave-assisted synthesis and physicochemical and cytocompatibility characterization [PDF]
, 2015 With the aim to produce mucoadhesive polymeric micelles for drug administration by mucosal routes, chitosan-g-oligo(epsilon-caprolactone) copolymers were synthesized by the microwave-assisted ring-opening polymerization of epsilon-caprolactone using ...
Calderon, Marcelo +5 more
core +1 more source