Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects [PDF]
, 2013 Nanocrystalline calcium phosphate apatites constitute the main inorganic part of hard tissues, and a growing focus is devoted to prepare synthetic analogs, so-called “biomimetic”, able to precisely mimic the morphological and physico-chemical features of
Delgado-López, José Manuel +4 more
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Lipid nanoparticles for administration of poorly water soluble neuroactive drugs
Biomedical Microdevices, 2017 This study describes the potential of solid lipid nanoparticles and nanostructured lipid carriers as nano-formulations to administer to the central nervous system poorly water soluble drugs. Different neuroactive drugs, i.e. dimethylfumarate, retinyl palmitate, progesterone and the endocannabinoid hydrolysis inhibitor URB597 have been studied.
ESPOSITO, Elisabetta +10 more
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Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques. [PDF]
Adv Pharmacol Pharm Sci, 2022 Abdullah Ali H, Kamal Omer H.
europepmc +1 more source
Asian Journal of Pharmaceutical Sciences, 2014 We applied a combination of inorganic mesoporous silica material, frequently used as drug carriers, and a natural organic polymer alginate (ALG), to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin (IND ...
Liang Hu +7 more
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Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles [PDF]
, 2017 Unimolecular branched polymer nanoparticles are formed in methanol via a simple thermal annealing process, which can be used to produce aqueous drug nanoparticle suspensions.
He, Tao +7 more
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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS
INDONESIAN JOURNAL OF PHARMACY, 2014 Aqueous solubility is a limiting factor in the oral bioavailability of a certain class of poorly water soluble drugs. A consequence of low aqueous solubility is a slow dissolution rate. For the drugs with low aqueous solubility and high permeability the dissolution rate will be the rate limiting step for absorption.
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Enhancement of the dissolution rates of poorly water-soluble drugs by water-soluble gelatin.
Chemical and Pharmaceutical Bulletin, 1989 The dissolution behavior of several acidic and basic drugs from kneaded mixtures with water-soluble gelatin have been studied in comparison with that of the drug alone. The results revealed a significant increase of dissolution rate of drugs from kneaded mixtures.
T, Imai +3 more
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Mechanistic study of the solubilization effect of basic amino acids on a poorly water-soluble drug. [PDF]
RSC Adv, 2022 Alsalhi MS, Royall PG, Chan KLA.
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Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]
, 2019 The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B. +6 more
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Novel polyvinylpyrrolidones to improve delivery of poorly-water soluble drugs; from design to synthesis and evaluation [PDF]
, 2012 Polyvinylpyrrolidone is a widely used in tablet formulations with the linear form acting as a wetting agent and disintegrant whereas the cross-linked form is a super-disintegrant.
Chappell, David +7 more
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