Results 81 to 90 of about 145,891 (201)

Automation potential of a new, rapid, microscopy based method for screening drug-polymer solubility [PDF]

, 2020
For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polymeric excipients can often be time-consuming because of the use of trial-and-error approaches.
Alhijjaj, Muqdad, Belton, Peter, Fabian, Laszlo, Qi, Sheng, Reading, Mike   +4 more
core   +1 more source

Supercritical Fluid Adsorption of Domperidone on Silica Aerogel [PDF]

, 2013
Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems.
Caputo, G.
core   +1 more source

Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

Asian Journal of Pharmaceutical Sciences
While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce
Jung Suk Kim, Seunghyun Cheon, Mi Ran Woo, Sanghyun Woo, Jee-Eun Chung, Yu Seok Youn, Kyung Taek Oh, Soo-Jeong Lim, Sae Kwang Ku, Bao Loc Nguyen, Jong Oh Kim, Sung Giu Jin, Han-Gon Choi   +12 more
doaj   +1 more source

Solubility Enhancement of Poorly Water-Soluble Drugs

International Journal of Advanced Research in Science, Communication and Technology
This article provides an overview of nanocrystals as a potentially valuable technology for enhancing the solubility of water-insoluble pharmaceuticals. Nanocrystals increase surface area by reducing particle size, hence improving bioavailability and solubility.
null Mr. Sufiyan Ahemad Abdul Mukthar, null Mr. Vishal Singh Solanki   +1 more
openaire   +1 more source

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation [PDF]

, 2015
Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the self-emulsifying drug delivery systems.
Benda L., FRANCESCHINIS, ERICA, Perssutti B., REALDON, NICOLA, SANTOMASO, ANDREA CLAUDIO, Voinovich D.   +5 more
core   +1 more source

The preparation of HEMA-MPC films for ocular drug delivery [PDF]

, 2017
There is a need to prolong drug residence time using a biocompatible formulation in the subconjunctival space after surgery to treat glaucoma. Drug releasing discs were prepared with 2-(hydroxyethyl)methacrylate (HEMA) and 2-methacryloyl-oxyethyl ...
Bettin, P. & Di Matteo, F.,, Brubaker, R.F.,, Chen, S. et al.,, Chong, R.S. et al.,, Cui, L. et al.,, Dhingra, S. & Khaw, P.,, Du, W. et al.,, Ethier, C.R., Johnson, M. & Ruberti, J.,, Hamilton, K.E. & Pye, D.C.,, Hoffman, A.S.,, Ishihara, K., Ueda, T. & Nakabayashi, N.,, Jhon, M.S. & Andrade, J.D.,, Kang-Mieler, J.J., Osswald, C.R. & Mieler, W.F.,, Kimura, H. et al.,, Kiritoshi, Y. & Ishihara, K.,, Kuppermann, B.D. & Loewenstein, A.,, Lee, H., Jhon, M. & Andrade, J.,, Lewis, A. et al.,, Lewis, A.L.,, Maurice, D.,, Monti, P. & Simonib, R.,, Morisaku, T. et al.,, Parkinson, G. et al.,, Rohindra, D., Nand, A. & Khurma,, Schlenoff, J.B.,, Shi, D.et al.,, Siggers, J.H. & Ethier, C.R.,, Skuta, G.L. et al.,, Stirbu, O. et al.,, Tomar, N. et al.,, Toris, C.B. et al.,, Tranoudis, I. & Efron, N.,, Vashist, A. et al.,, Weinreb, R.N. & Khaw, P.T.,, Young, G. et al.,   +34 more
core   +2 more sources

Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update

Journal of Pharmacy & Pharmaceutical Sciences, 2016
The formulation development for poorly soluble drugs still remains a challenge. Supersaturating drug delivery systems (SDDS) or drug delivery systems based on supersaturating provide a promising way to improve the oral bioavailability of poorly water ...
Meiyan Yang, Wei Gong, Yuli Wang, Li Shan, Ying Li, Chunsheng Gao   +5 more
doaj   +1 more source

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]

, 2014
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
Allemandi, Daniel Alberto, Castro, Silvina Gabriela, González Vidal, Noelia Luján, Palma, Santiago Daniel, Sanchez Bruni, Sergio Fabian   +4 more
core   +1 more source

Efficient Drug Loading Method for Poorly Water-Soluble Drug into Bicelles through Passive Diffusion. [PDF]

Mol Pharm, 2023
Arai Y, Iwao Y, Muguruma Y, Yamamoto K, Ikeda Y.   +4 more
europepmc   +1 more source

Liquid-filled hard gelatin capsules : excipient/capsule compatibility studies [PDF]

, 2016
Encapsulation of pharmaceutical formulations as liquids or semisolids, within hard gelatin capsules, presents an important oral dosage strategy for poorly water-soluble drugs, resulting in good bioavailability and reproducible drug absorption.
Halbert, G. W., Harkins, D., Kreiner, M., Rae, K., Thayne, N.   +4 more
core