Results 111 to 120 of about 7,969,000 (286)
Journal of Pharmacy & Pharmaceutical Sciences, 2016 The formulation development for poorly soluble drugs still remains a challenge. Supersaturating drug delivery systems (SDDS) or drug delivery systems based on supersaturating provide a promising way to improve the oral bioavailability of poorly water ...
Meiyan Yang +5 more
doaj +1 more source
Mechanistic study of the solubilization effect of basic amino acids on a poorly water-soluble drug. [PDF]
RSC Adv, 2022 Alsalhi MS, Royall PG, Chan KLA.
europepmc +1 more source
SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS
INDONESIAN JOURNAL OF PHARMACY, 2014 Aqueous solubility is a limiting factor in the oral bioavailability of a certain class of poorly water soluble drugs. A consequence of low aqueous solubility is a slow dissolution rate. For the drugs with low aqueous solubility and high permeability the dissolution rate will be the rate limiting step for absorption.
openaire +3 more sources
Enhancement of the dissolution rates of poorly water-soluble drugs by water-soluble gelatin.
Chemical and Pharmaceutical Bulletin, 1989 The dissolution behavior of several acidic and basic drugs from kneaded mixtures with water-soluble gelatin have been studied in comparison with that of the drug alone. The results revealed a significant increase of dissolution rate of drugs from kneaded mixtures.
IMAI, Teruko +3 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli +8 more
wiley +1 more source
Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition. [PDF]
Pharmaceuticals (Basel), 2021 Lee JH +5 more
europepmc +1 more source
Strategies in poorly soluble drug delivery systems [PDF]
, 2018 The form of the active drug administered to patients is important as far as effectiveness of the disease therapy is concerned. From this point of view modifications of medicinal substances are searched for that the obtained compounds have the best ...
Szaniawska, Magdalena
core +1 more source
Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers
Advanced Healthcare Materials, EarlyView.Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li +9 more
wiley +1 more source
Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution
Advanced Healthcare Materials, EarlyView.Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko +7 more
wiley +1 more source