Evaluation of lipid-based formulations of poorly water-soluble drugs in the gastro-intestinal tract using in vitro tests [PDF]
, 2011 Novel active pharmaceutical ingredients are often poorly water-soluble. Such compounds may only partially dissolve or may precipitate during intestinal passage, potentially leading to incomplete drug absorption. Despite the importance of the process, the
Arnold, Yvonne Elisabeth
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Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]
, 2013 In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
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Drug-excipient-shell interactions using thermoplastic starch-based capsules for oral lipid-based drug delivery [PDF]
, 2014 Worldwide, gelatin has been used in the rotary die process as a shell-forming material of soft capsules due to its unique physicochemical properties.
Misic, Zdravka
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Insoluble drug delivery strategies: review of recent advances and business prospects
Acta Pharmaceutica Sinica B, 2015 The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
Sandeep Kalepu, Vijaykumar Nekkanti
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Solid self‑emulsifying pellets: Solubility enhancement for oral delivery of poorly soluble BCS Class II drug [PDF]
, 2022 The review focused on technique of solid self-emulsifying pellets (SEPs) for solubility enhancement of poorly water soluble drug. The oral route of administration has been and still is currently the primary route of drug delivery owing to its potential ...
Ukhade, Snehal Sampat +4 more
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Influence of mannitol and sorbitol on the in vitro dissolution of a model poorly water-soluble drug [PDF]
, 2022 This paper is intended to investigate the effect of different forms of mannitol and a combination of mannitol and sorbitol on the in vitro dissolution of a model poorly water-soluble drug.
Makraduli, Liljana +7 more
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Journal of Pharmacy and Bioallied Sciences, 2012 Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity.
A Lodha +6 more
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British Journal of Pharmacy, 2023 Forming amorphous solid dispersions (ASDs) is one method for improving the solubility and subsequent absorption of poorly-water soluble drugs. An ASD is a matrix of a poorly water-soluble compound with a hydrophilic polymer carrier, which stabilises ...
Elen Roberts +8 more
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Nanosuspension: An approach to enhance solubility of drugs
Journal of Advanced Pharmaceutical Technology & Research, 2011 One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media ...
Vishal R Patel, Y K Agrawal
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Lipid nanoparticles for the delivery of poorly water-soluble drugs [PDF]
Journal of Pharmacy and Pharmacology, 2010 Abstract Objectives This review discusses important aspects of lipid nanoparticles such as colloidal lipid emulsions and, in particular, solid lipid nanoparticles as carrier systems for poorly water-soluble drugs, with a main focus on the parenteral and peroral use of these carriers.
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