Results 21 to 30 of about 50,651 (209)

Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs

Frontiers in Drug Delivery, 2023
Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy.
Popat Mohite, Sudarshan Singh, Anil Pawar, Adinath Sangale, Bhupendra G. Prajapati   +4 more
doaj   +1 more source

Development of a Self-Assembled Hydrogels Based on Carboxymethyl Chitosan and Oxidized Hyaluronic Acid Containing Tanshinone Extract Nanocrystals for Enhanced Dissolution and Acne Treatment

Pharmaceuticals, 2022
This study aimed to construct a pH-responsive nanocrystalline hydrogel drug delivery system for topical delivery of insoluble drugs based on the self-assembly behavior of carboxymethyl chitosan (CMC) and oxidized hyaluronic acid (OHA).
Xiaohan Tang, Yan Liu, Hailong Yuan, Rong Gao   +3 more
doaj   +1 more source

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

Molecules, 2015
Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery.
Matthew McKenzie, David Betts, Amy Suh, Kathryn Bui, London Doyoung Kim, Hyunah Cho   +5 more
doaj   +1 more source

Development of pectin nanoparticles through mechanical homogenization for dissolution enhancement of itraconazole

Asian Journal of Pharmaceutical Sciences, 2016
A simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from nanoemulsion templates is described in this study. Nanoemulsions containing ITZ were prepared by a mechanical homogenization using pectin as emulsifier.
Kanokporn Burapapadh, Hirofumi Takeuchi, Pornsak Sriamornsak   +2 more
doaj   +1 more source

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs

Pharmaceutics, 2018
Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang, Huijie Xing, Yue Zhao, Zhiguo Ma   +3 more
doaj   +1 more source

Insoluble drug delivery strategies: review of recent advances and business prospects

Acta Pharmaceutica Sinica B, 2015
The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
Sandeep Kalepu, Vijaykumar Nekkanti
doaj   +1 more source

Model Informed-Development of Amorphous Systems (MI-DAS) - an in-silico polymer selection tool for ASD development

British Journal of Pharmacy, 2023
Forming amorphous solid dispersions (ASDs) is one method for improving the solubility and subsequent absorption of poorly-water soluble drugs. An ASD is a matrix of a poorly water-soluble compound with a hydrophilic polymer carrier, which stabilises ...
Elen Roberts, Sadiyah Rahman, Shajee Ahmed, Harri Dickinson , Parmesh Gajjar, Talbir Austin, Shanoo Budhdeo, Marcel de Matas, Paul Stott   +8 more
doaj   +1 more source

Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A

Journal of Pharmacy and Bioallied Sciences, 2012
Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity.
A Lodha, M Lodha, A Patel, J Chaudhuri, J Dalal, M Edwards, D Douroumis   +6 more
doaj   +1 more source

Solubility and Stability of Some Pharmaceuticals in Natural Deep Eutectic Solvents-Based Formulations

Molecules, 2021
Some medicines are poorly soluble in water. For tube feeding and parenteral administration, liquid formulations are required. The discovery of natural deep eutectic solvents (NADES) opened the way to potential applications for liquid drug formulations ...
Natali Rianika Mustafa, Vincent Simon Spelbos, Geert-Jan Witkamp, Robert Verpoorte, Young Hae Choi   +4 more
doaj   +1 more source