Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®
Molecules, 2015 Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Jinwen Liu +7 more
doaj +1 more source
Development and Physicochemical Characterization of Sirolimus Solid Dispersions Prepared by Solvent Evaporation Method [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties.
Shahram Emami +3 more
doaj +1 more source
Effect of molecular interactions on properties of amorphous solid dispersions
, 2021 Amorphous solid dispersions have been widely applied to improve the oral bioavailability of BCS Class II and Class IV compounds by increasing their kinetic solubility and dissolution rate.
Meng, Fan
core +1 more source
Pharmaceutics, 2019 The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be high among the scientific community.
Piyush Panini +4 more
doaj +1 more source
Manufacturing strategies to develop amorphous solid dispersions: An overview [PDF]
Journal of Drug Delivery Science and Technology, 2020 Since the past several decades, poor water solubility of existing and new drugs in the pipeline have remained a challenging issue for the pharmaceutical industry. Literature describes several approaches to improve the overall solubility, dissolution rate, and bioavailability of drugs with poor water solubility.
Nicole, Mendonsa +6 more
openaire +2 more sources
The solid-state modification for solubility enhancement of practically insoluble glimepiride: A systematic review [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Solubility is a crucial physicochemical property of pharmaceuticals that directly influences the absorption and bioavailability of drugs within the human body.
Fitrianti Darusman +3 more
doaj +1 more source
Pharmaceutics, 2020 This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system.
Sooho Yeo +4 more
doaj +1 more source
Evaluation of the impact of surfactants on miscibility of griseofulvin in spray dried amorphous solid dispersions [PDF]
, 2021 The aim of this contribution is to examine the impact of incorporating surfactants into amorphous solid dispersions on solid state miscibility and aqueous solubility of the antifungal drug griseofulvin.
Al-Obaidi, Hisham +2 more
core +1 more source
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF KETOTIFEN BY SOLID DISPERSION TECHNIQUE [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2015 Ketotifen (KT) solid dispersions and physical mixtures were prepared with the objective of solubility and dissolution improvement using Hydroxypropyl-Beta-Cyclodextrin (HP-β-CD), Pluronic 127 (PF-127), Pluronic 68 (PF-68), Polyethylene glycol 6000 (PEG ...
Omnia Mahmoud +2 more
doaj +1 more source
Whey proteins as stabilizers in amorphous solid dispersions
European Journal of Pharmaceutical Sciences, 2019 Whey proteins are extensively used as nutritional supplements but have so far not been investigated as co-formers for amorphous solid dispersions (ASD) to enhance the solubility and dissolution rate of poorly water soluble drugs. In this study, whey protein isolate (WPI) and whey protein hydrolysate (WPH) were each mixed with three poorly water soluble
Jaya Mishra +4 more
openaire +3 more sources