Results 31 to 40 of about 1,873,271 (247)

Effect of molecular interactions on properties of amorphous solid dispersions [PDF]

, 2020
Amorphous solid dispersions have been widely applied to improve the oral bioavailability of BCS Class II and Class IV compounds by increasing their kinetic solubility and dissolution rate.
Meng, Fan
core   +1 more source

Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

Pharmaceutics, 2018
In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and ...
Poovizhi Ponnammal, Parijat Kanaujia, Yin Yani, Wai Kiong Ng, Reginald B. H. Tan   +4 more
doaj   +1 more source

The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Frontiers in Molecular Biosciences, 2023
Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports ...
Haibin Wang, Yingying Lu, Haisong Yang, Deng-Guang Yu, Xuhua Lu   +4 more
doaj   +1 more source

Compression-Induced Phase Transitions of Bicalutamide

Pharmaceutics, 2020
The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improves the dissolution characteristics of poorly soluble drugs.
Joanna Szafraniec-Szczęsny, Agata Antosik-Rogóż, Justyna Knapik-Kowalczuk, Mateusz Kurek, Ewa Szefer, Karolina Gawlak, Krzysztof Chmiel, Sebastian Peralta, Krzysztof Niwiński, Krzysztof Pielichowski, Marian Paluch, Renata Jachowicz   +11 more
doaj   +1 more source

Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

Pharmaceutics, 2023
Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral ...
Hannes Gierke, Susan Mouchantat, Sabine Berg, Michael Grimm, Stefan Hadlich, Marie-Luise Kromrey, Thomas Nolte, Teresa Pfrommer, Vincent Rönnpagel, Adrian Rump, Kerstin Schaefer, Ann-Cathrin Willmann, Werner Weitschies   +12 more
doaj   +1 more source

Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®

Molecules, 2015
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Jinwen Liu, Meijuan Zou, Hongyu Piao, Yi Liu, Bo Tang, Ying Gao, Ning Ma, Gang Cheng   +7 more
doaj   +1 more source

Development and Physicochemical Characterization of Sirolimus Solid Dispersions Prepared by Solvent Evaporation Method [PDF]

Advanced Pharmaceutical Bulletin, 2014
Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties.
Shahram Emami, Hadi Valizadeh, Ziba Islambulchilar, Parvin Zakeri-Milani   +3 more
doaj   +1 more source

Myth or Truth: The Glass Forming Ability Class III Drugs Will Always Form Single-Phase Homogenous Amorphous Solid Dispersion Formulations

Pharmaceutics, 2019
The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be high among the scientific community.
Piyush Panini, Massimiliano Rampazzo, Abhishek Singh, Filip Vanhoutte, Guy Van den Mooter   +4 more
doaj   +1 more source

Stabilized amorphous solid dispersions with small molecule excipients

, 2014
Chapter 21.
Jensen, Katrine Birgitte Tarp, Strachan, Clare, Löbmann, Korbinian, Laitinen, Riikka, Rades, Thomas, Grohganz, Holger   +5 more
core   +2 more sources

The solid-state modification for solubility enhancement of practically insoluble glimepiride: A systematic review [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Solubility is a crucial physicochemical property of pharmaceuticals that directly influences the absorption and bioavailability of drugs within the human body.
Fitrianti Darusman, Iyan Sopyan, Nadya Azzahra, Taofik Rusdiana   +3 more
doaj   +1 more source