Results 51 to 60 of about 2,406 (250)

Low‐Cost, Large‐Scale Nanoporous Metals by Mechanical Alloying, Oxide Reduction, and Dealloying of Powders

Advanced Engineering Materials, EarlyView.
Powder metal processing provides scalable advantages in nanoporous (np) metal development. Mechanical alloying is used to produce unique precursors for hybrid nanopore formation by oxide reduction and dealloying. As demonstrated in np Ag, this approach improves process efficiency while promoting smaller ligaments and larger pores, both of which are ...
Mark A. Atwater, Oliver A. Fowler
wiley   +1 more source

Nimodipino: do polimorfismo à obtenção de dispersões sólidas amorfas destinadas ao tratamento da hipertensão arterial [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.A baixa solubilidade de fármacos apresenta-se como um dos aspectos mais desafiadores no ...
Riekes, Manoela Klüppel
core  

Application of hot-melt extrusion in the manufacturing of amorphous solid dispersions containing thermally labile drugs [PDF]

, 2017
Hot-melt extrusion has gained favor over traditional pharmaceutical formulation techniques in bioavailability/solubility enhancement because it is a solvent-free and continuous operation process that does not require major downstream processing. However,
Huang, Siyuan, 1989-
core   +1 more source

Field Report from Collaborative Research Center 1625: Heterogeneous Research Data Management Using Ontology Representations

Advanced Engineering Materials, EarlyView.
A unified research data management framework for heterogeneous materials data is presented. The system integrates multimodal datasets using ontologies and knowledge graphs, enabling interoperability and FAIR (findable, accessible, interoperable, reusable) data principles. By linking data across scales and workflows, it supports reproducible, Artifitial
Doaa Mohamed, Samuel García Vázquez, Behnam Mardani, Victor Dudarev, Alfred Ludwig, Maribel Acosta, Markus Stricker   +6 more
wiley   +1 more source

Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions

, 2016
It has been technically challenging to specify the detailed molecular interactions and binding motif between drugs and polymeric inhibitors in the solid state.
Anthony Leone (1801816), Stephen R. Byrn (1386339), Tonglei Li (1574197), Haichen Nie (1415980), Patrick J. Marsac (811779), Mingtao Zhang (832481), Yang Song (1235364), Lynne S. Taylor (1349709), Yongchao Su (1317195)   +8 more
core   +1 more source

Clozapine-carboxylic acid plasticized co-amorphous dispersions: Preparation, characterization and solution stability evaluation

Acta Pharmaceutica, 2015
This study addressed the possibility of forming of co-amorphous systems between clozapine (CZ) and various carboxylic acid plasticizers (CAPs). The aim was to improve the solubility and oral bioavailability of clozapine.
Ali Ahmed Mahmoud Abdelhaleem, Ali Adel Ahmed, Maghrabi Ibrahim Abdullah   +2 more
doaj   +1 more source

Abstract 10 — Enhancing Dissolution Efficiency of Ketoprofen, A Rheumatoid Arthritis Pain Management Drug, through Solid Dispersion Formulation

Journal of Clinical Rheumatology and Immunology, 2023
Background Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA). However, KETO belongs to the BCS class-II category, characterized by poor water solubility, resulting in less dissolution capability leading
Pankajkumar Yadav
doaj   +1 more source

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source

Affecting the Properties of Copper–Graphene Electroconductive Composite by Severe Plastic Deformation

Advanced Engineering Materials, EarlyView.
Copper‐based composites enhanced with carbon feature convenient mechanical properties and favorable electric conductivity. Processing via deformation and thermomechanical treatments can introduce advantageous microstructures further enhancing their performance. Herein, copper–graphene powder‐based composites are directly consolidated via rotary swaging
Radim Kocich, Lenka Kunčická, Pavel Czernek, Zifan Wang   +3 more
wiley   +1 more source

Theoretical Considerations in Developing Amorphous Solid Dispersions

, 2014
Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route
Clare J. Strachan, Sachin Surwase, Strachan, Clare J., Priemel, Petra Alexandra, Surwase, Sachin, Grohganz, Holger, Rades, Thomas, Holger Grohganz, Riikka Laitinen, Petra A. Priemel, Kirsten Graeser, Laitinen, Riikka, Thomas Rades, Graeser, Kirsten   +13 more
core   +1 more source