Results 51 to 60 of about 1,873,271 (247)
Acta Pharmaceutica, 2015 This study addressed the possibility of forming of co-amorphous systems between clozapine (CZ) and various carboxylic acid plasticizers (CAPs). The aim was to improve the solubility and oral bioavailability of clozapine.
Ali Ahmed Mahmoud Abdelhaleem +2 more
doaj +1 more source
Rapidly Solidified High‐Strength Invar 36 Prepared by Planar‐Flow Melt Spinning
Advanced Engineering Materials, EarlyView.The Invar 36 alloy was rapidly solidified using the planar‐flow melt‐spinning technique. Ribbon samples with thicknesses ranging from 20 to 160 mm were produced. As the grain size of the ribbon decreased to sub‐micron levels, the hardness increased by more than 2 times.
Bekir Akgül, Mehmet Kul
wiley +1 more source
Enhancing delivery of poorly water-soluble drugs by innovative amorphous solid dispersions [PDF]
, 2022 Poorly water-soluble drugs continue to dominate today’s drug development pipelines, and thus a multitude of technologies and solubility-enhancing methodologies have been commercialized to address this issue. One-such methodology to enhance the solubility
Jermain, Scott Victor
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Advanced Engineering Materials, EarlyView.This perspective reframes additive manufacturing for electrical machines as a qualification‐limited materials and architecture design problem. It links process–structure–property–performance relationships to magnetic, conducting, dielectric, and thermal property windows, highlighting where AM can enable segmented magnetic circuits, permanent magnet ...
Dénes Fodor, Loránd Szabó
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Journal of Clinical Rheumatology and Immunology, 2023 Background Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA). However, KETO belongs to the BCS class-II category, characterized by poor water solubility, resulting in less dissolution capability leading
Pankajkumar Yadav
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Theoretical Considerations in Developing Amorphous Solid Dispersions
, 2014 Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route
Clare J. Strachan +13 more
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Elastic–Plastic Modeling and Experimental Characterization of Granular Jamming Actuators
Advanced Engineering Materials, EarlyView.Granular jamming enables rapid switching between soft and rigid mechanical states. Here, a reduced‐order elastic‐perfectly‐plastic beam framework captures pressure‐dependent loading, unloading, residual deformation, and hysteresis in jammed beams, while matching three‐point bending experiments across materials and geometries. The framework links design
Saheli Patel +2 more
wiley +1 more source
Electrodeposition in Structural Lattices of Variable Architectures
Advanced Engineering Materials, EarlyView.Electrodeposition enables geometry‐sensitive, autonomous void filling while simultaneously tuning chemical and mechanical properties. The development of approaches that can autonomously fill and heal material voids and yield composites with tailorable properties is increasingly relevant in engineering.
Yeong‐Man Kwon +3 more
wiley +1 more source
Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery
Pharmaceutics, 2018 Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been ...
Laura Modica de Mohac +3 more
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Micro-Injection Moulding of PEO/PCL Blend–Based Matrices for Extended Oral Delivery of Fenbendazole
Pharmaceutics, 2023 Fenbendazole (FBZ) is a broad-spectrum anthelmintic administered orally to ruminants; nevertheless, its poor water solubility has been the main limitation to reaching satisfactory and sustained levels at the site of the target parasites.
Gilberto S. N. Bezerra +5 more
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