Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process [PDF]
Pharmaceutics, 2018 Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing numerous types of drug delivery systems and dosage forms. It offers several advantages: no solvents are required, it is easy to scale up and employ on the industrial
Roberta Censi +3 more
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Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion [PDF]
Pharmaceutics, 2023 Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients.
Judith Winck +2 more
doaj +4 more sources
Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion [PDF]
Pharmaceutics, 2022 Even though hot melt extrusion (HME) is a commonly applied process in the pharmaceutical area, determination of the optimal process parameters is demanding.
Tobias Gottschalk +3 more
doaj +4 more sources
Material-Sparing Feasibility Screening for Hot Melt Extrusion [PDF]
PharmaceuticsHot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are typically aimed at ...
Amanda Pluntze +4 more
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Vertical Hot-Melt Extrusion: The Next Challenge in Innovation [PDF]
PharmaceuticsBackground/Objectives: Hot-melt extrusion (HME) has become a key technology in pharmaceutical formulation, particularly for enhancing the solubility of poorly soluble Active Pharmaceutical Ingredients (APIs).
Maël Gallas +3 more
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Applications of hot-melt extrusion for drug delivery [PDF]
Expert Opinion on Drug Delivery, 2008 In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously ...
Michael Repka +2 more
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Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate [PDF]
Pharmaceutics, 2022 The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME).
Lena Hoffmann +2 more
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Hot-Melt Extrusion Enhances Antioxidant Effects of Mulberry on Probiotics and Pathogenic Microorganisms [PDF]
Antioxidants, 2022 Mulberry is a rich source of anthocyanins (ACNs) known to possess biological activities. However, these ACNs are unstable in high pH, heat, and aqueous environments with a low bioavailability.
Eun Ji Go +10 more
doaj +2 more sources
Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
Pharmaceutics, 2018 A validation for the use of model-based melt viscosity in hot-melt extrusion numerical simulations was presented. Here, the melt viscosity of an amorphous solid dispersion (ASD) was calculated by using its glass transition temperature (Tg) and the ...
Esther S. Bochmann +2 more
doaj +3 more sources
Towards predicting the product quality in hot-melt extrusion: Small scale extrusion
International Journal of Pharmaceutics: X, 2020 In product development, it is crucial to choose the appropriate drug manufacturing route accurately and timely and to ensure that the technique selected is suitable for achieving the desired product quality.
Josip Matić +6 more
doaj +3 more sources