Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process [PDF]
Pharmaceutics, 2018 Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing numerous types of drug delivery systems and dosage forms. It offers several advantages: no solvents are required, it is easy to scale up and employ on the industrial
Roberta Censi +3 more
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Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion [PDF]
Pharmaceutics, 2023 Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients.
Judith Winck +2 more
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Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion [PDF]
Pharmaceutics, 2022 Even though hot melt extrusion (HME) is a commonly applied process in the pharmaceutical area, determination of the optimal process parameters is demanding.
Tobias Gottschalk +3 more
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Material-Sparing Feasibility Screening for Hot Melt Extrusion [PDF]
PharmaceuticsHot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are typically aimed at ...
Amanda Pluntze +4 more
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Vertical Hot-Melt Extrusion: The Next Challenge in Innovation [PDF]
PharmaceuticsBackground/Objectives: Hot-melt extrusion (HME) has become a key technology in pharmaceutical formulation, particularly for enhancing the solubility of poorly soluble Active Pharmaceutical Ingredients (APIs).
Maël Gallas +3 more
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Pharmaceutical Hot Melt Extrusion [PDF]
Scientia Pharmaceutica, 2010 Hot Melt Extrusion, proven state-of-the-art technology in the field of plastics, is becoming increasingly important in the pharmaceutical industry. [...]
N. NEUB
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Applications of hot-melt extrusion for drug delivery [PDF]
Expert Opinion on Drug Delivery, 2008 In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously ...
Michael A Repka +2 more
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Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate [PDF]
Pharmaceutics, 2022 The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME).
Lena Hoffmann +2 more
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Novel Applications of Hot Melt Extrusion Technology
Journal of Drug Delivery and Therapeutics, 2023 Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there were several developments in HME technology to utilize it effectively for the manufacturing of pharmaceuticals.
Biplab Kumar Dey +4 more
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Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique
Iraqi Journal of Pharmaceutical Sciences, 2018 The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized.
Ahmed S. Abdul Jabbar
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