Results 11 to 20 of about 917,915 (175)
Hot‐Melt Extrusion: Pharmaceutical Applications [PDF]
, 2012 Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and ...
Douroumis, Dennis
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Pharmaceutical Hot Melt Extrusion [PDF]
Scientia Pharmaceutica, 2010 Hot Melt Extrusion, proven state-of-the-art technology in the field of plastics, is becoming increasingly important in the pharmaceutical industry. [...]
N. NEUB, null NEUB
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Pharmaceutics, 2019 Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals [...]
Mohammed Maniruzzaman
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Novel Applications of Hot Melt Extrusion Technology [PDF]
Journal of Drug Delivery and Therapeutics, 2023 Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there were several developments in HME technology to utilize it effectively for the manufacturing of pharmaceuticals.
Biplab Kumar Dey +4 more
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Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique
Iraqi Journal of Pharmaceutical Sciences, 2018 The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized.
Ahmed S. Abdul Jabbar
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Towards predicting the product quality in hot-melt extrusion: Small scale extrusion
International Journal of Pharmaceutics: X, 2020 In product development, it is crucial to choose the appropriate drug manufacturing route accurately and timely and to ensure that the technique selected is suitable for achieving the desired product quality.
Josip Matić +6 more
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Process monitoring and visualization solutions for hot-melt extrusion: a review [PDF]
Journal of Pharmacy and Pharmacology, 2014 Abstract Objectives Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations. To ensure the continuity of this process, the quality of the extrudates must be assessed continuously during manufacturing. The
Saerens, Lien +3 more
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Drug Design, Development and Therapy, 2015 Jae-Young Lee,1,* Wie-Soo Kang,2,* Jingpei Piao,2 In-Soo Yoon,3 Dae-Duk Kim,1 Hyun-Jong Cho4 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 2School of Bioscience and Biotechnology, Kangwon ...
Lee JY +5 more
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Inline Determination of Residence Time Distribution in Hot-Melt-Extrusion [PDF]
Pharmaceutics, 2018 In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a ...
Jens Wesholowski +2 more
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Pharmaceutics, 2020 The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD ...
Sung-Min Choi +3 more
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