Results 21 to 30 of about 16,706 (282)
Hot-Melt Extrusion Enhances Antioxidant Effects of Mulberry on Probiotics and Pathogenic Microorganisms [PDF]
Antioxidants, 2022 Mulberry is a rich source of anthocyanins (ACNs) known to possess biological activities. However, these ACNs are unstable in high pH, heat, and aqueous environments with a low bioavailability.
Eun Ji Go +10 more
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Pharmaceutics, 2019 Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals [...]
Mohammed Maniruzzaman
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Towards predicting the product quality in hot-melt extrusion: Small scale extrusion
International Journal of Pharmaceutics: X, 2020 In product development, it is crucial to choose the appropriate drug manufacturing route accurately and timely and to ensure that the technique selected is suitable for achieving the desired product quality.
Josip Matić +6 more
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Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
Pharmaceutics, 2018 A validation for the use of model-based melt viscosity in hot-melt extrusion numerical simulations was presented. Here, the melt viscosity of an amorphous solid dispersion (ASD) was calculated by using its glass transition temperature (Tg) and the ...
Esther S. Bochmann +2 more
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Application of Lipids in Hot Melt Extrusion Technology
Journal of Drug Delivery and Therapeutics, 2023 Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism through nanoparticulate approach, modifying the drug release, binders, permeation enhancers, transfection agents etc.
Mounika Rajya Lakshmi Kodam +1 more
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Inline Determination of Residence Time Distribution in Hot-Melt-Extrusion [PDF]
Pharmaceutics, 2018 In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a ...
Jens Wesholowski +2 more
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In-process rheometry as a PAT tool for hot melt extrusion [PDF]
Drug Development and Industrial Pharmacy, 2017 Real time measurement of melt rheology has been investigated as a Process Analytical Technology (PAT) to monitor hot melt extrusion of an Active Pharmaceutical Ingredient (API) in a polymer matrix. A developmental API was melt mixed with a commercial copolymer using a heated twin screw extruder at different API loadings and set temperatures.
Kelly, Adrian L. +7 more
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Improving the Pharmaceutical Potential of Lycopene Using Hot-Melt Extrusion
Applied SciencesBackground: Lycopene is a powerful antioxidant, classified as a carotenoid. Numerous studies confirm its beneficial effects in both the prevention and treatment of various diseases. However, its therapeutic application is significantly limited due to its
Anna Kulawik +6 more
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Drug Design, Development and Therapy, 2015 Jae-Young Lee,1,* Wie-Soo Kang,2,* Jingpei Piao,2 In-Soo Yoon,3 Dae-Duk Kim,1 Hyun-Jong Cho4 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 2School of Bioscience and Biotechnology, Kangwon ...
Lee JY +5 more
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Process monitoring and visualization solutions for hot-melt extrusion: a review [PDF]
Journal of Pharmacy and Pharmacology, 2014 Abstract Objectives Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations. To ensure the continuity of this process, the quality of the extrudates must be assessed continuously during manufacturing. The
Saerens, Lien +3 more
openaire +4 more sources