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Разработка и регистрация лекарственных средств, 2022 Introduction. The solubility of an active pharmaceutical ingredient plays a major role in drug absorption. Hot melt extrusion is a batch or continuous process that allows creating solid dispersion systems based on various carriers in order to increase ...
K. A. Gusev +7 more
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Recent development, challenges, and prospects of extrusion technology
Future Foods, 2021 There is a significant advancement in the modification of extruders for the commercial application in food processing sector, especially during the last three decades.
Krishna Prabha +6 more
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Factors That Influence Sustained Release from Hot-Melt Extrudates
Pharmaceutics, 2023 Hot-melt extrusion is a well-established tool in the pharmaceutical industry, mostly implemented to increase the solubility of poorly soluble drugs. A less frequent application of this technique is to obtain formulations with extended release. This study
Yaser Mansuroglu, Jennifer Dressman
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Hot‐Melt Extrusion: Pharmaceutical Applications [PDF]
, 2012 Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and ...
Douroumis, Dennis
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Journal of Materials Research and Technology, 2022 Grain refinement with a facile process without additional alloying is quite desired for strengthening the Al alloys. Using the melt spinning process, we obtained the ultra-fine grained foils of Al–Mg–Si–Cu alloy (AA6061), then the foils followed by hot ...
Shuoxun Jin +5 more
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A Review of Dynamic Models of Hot-Melt Extrusion [PDF]
Processes, 2016 Hot-melt extrusion is commonly applied for forming products, ranging from metals to plastics, rubber and clay composites. It is also increasingly used for the production of pharmaceuticals, such as granules, pellets and tablets. In this context, mathematical modeling plays an important role to determine the best process operating conditions, but also ...
Grimard, Jonathan +2 more
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Pharmaceutics, 2020 The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD ...
Sung-Min Choi +3 more
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Разработка и регистрация лекарственных средств, 2023 Introduction. Ebastine is a second-generation antihistamine drug available in the form of orally disintegrating tablets and film-coated tablets. Ebastine substance exhibits high bioavailability, but low solubility in water and gastrointestinal tract ...
K. A. Gusev +7 more
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Influence of degassing on hot-melt extrusion process [PDF]
European Journal of Pharmaceutical Sciences, 2015 The present study aimed to evaluate the effect of degassing on an extrusion process, with respect to extrudate quality and drug release properties. Processed formulations were extruded with and without a degassing vent port at various locations along the barrel. All the experiments were performed under constant processing temperature, feeding rate, and
Saad M, Alshahrani +5 more
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FROM CONCEPT TO DELIVERY: THE EVOLUTION AND APPLICATIONS OF HOT-MELT EXTRUSION IN PHARMACEUTICALS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityHot Melt Extrusion (HME) is an innovative approach that is currently receiving significant interest in the pharmaceutical sector for the manufacturing of various dosage forms.
Jigar Vyas, Nensi Raytthatha
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