Asian Journal of Pharmaceutical Sciences, 2017 The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid (OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion (HME) was applied to develop OA amorphous solid dispersions.
Nannan Gao +3 more
doaj +1 more source
Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion - II: Cellulosic polymers [PDF]
, 2016 The purpose of this study was to determine the thermal and viscoelastic properties of cellulosic polymers that may have potential for use in hot melt extrusion (HME). Cellulose ethers of different molecular weight (MW) with varied degrees of substitution
Simerdeep Singh Gupta +3 more
core
Materials & DesignRising demand for biomedical devices requires manufacturing approaches suitable for processing thermally-sensitive materials. Hot-melt extrusion may cause thermal degradation of polymers and bioactives.
Philbert Nshimiyimana +3 more
doaj +1 more source
3D-Printed Tablets of Nifurtimox: In Vitro and In Vivo Anti-Trypanosoma cruzi Studies
PharmaceuticsBackground/Objectives: Chagas disease is a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi. Benznidazole and nifurtimox are the only approved drugs for treating this condition, but their low aqueous solubility may lead ...
Giselle R. Bedogni +6 more
doaj +1 more source
Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion - III: Polymethacrylates and polymethacrylic acid based polymers [PDF]
, 2016 Polymers are a major part of final medicinal drug products prepared by hot melt extrusion (HME). Therefore it is necessary to understand their behavior when subjected to heat and mechanical stresses during the development of the HME processes. The aim of
Simerdeep Singh Gupta +3 more
core
Material Considerations for Fused-Filament Fabrication of Solid Dosage Forms
Pharmaceutics, 2018 Material choice is a fundamental consideration when it comes to designing a solid dosage form. The matrix material will ultimately determine the rate of drug release since the physical properties (solubility, viscosity, and more) of the material control ...
Evert Fuenmayor +6 more
doaj +1 more source
Implications of plasticization on the properties of hot-melt extruded oral dosage forms [PDF]
, 2009 textThe influence of plasticization and other formulation factors on the properties of hot-melt extruded dosage forms for the controlled release of water-soluble active compounds was investigated. Citric acid monohydrate was demonstrated to function as a
Schilling, Sandra Ursula
core
Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion - I: Polyvinylpyrrolidone and related polymers [PDF]
, 2016 Polymers are essential components of melt extruded products. The objective of the present study was to generate physicochemical data of polyvinylpyrrolidone-based polymers and copolymers that are used in hot melt extrusion (HME).
Simerdeep Singh Gupta +3 more
core
Journal of Applied Pharmaceutical ResearchBackground: Conversion of poorly soluble drugs into amorphous solid dispersions using different carriers is a formulation approach to improve solubility.
Lakshmi Swapna Sai +3 more
doaj +1 more source
Production of enteric capsules by means of hot-melt extrusion
European Journal of Pharmaceutical Sciences, 2005 The aim of this study was to develop an alternative technique for enteric coating consisting of the hot-melt extrusion of coating polymers. An enteric coating polymer (PVAP or HPMC AS), premixed with a plasticizer, was extruded into hollow cylinders.
Els, Mehuys +2 more
openaire +2 more sources