Results 41 to 50 of about 16,706 (282)

Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion

Pharmaceutics, 2020
To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in ...
Martin Spoerk, Ioannis Koutsamanis, Josip Matić, Simone Eder, Carolina Patricia Alva Zúñiga, Johannes Poms, Jesús Alberto Afonso Urich, Raymar Andreína Lara García, Klaus Nickisch, Karin Eggenreich, Andreas Berghaus, Kathrin Reusch, Yorick Relle, Johannes Khinast, Amrit Paudel   +14 more
doaj   +1 more source

Microstructure and refinement mechanism of Al–5Ti–1B alloys

Fenmo yejin jishu, 2022
Two kinds of Al–5Ti–1B alloys were prepared by powder mixing + hot extrusion and powder mixing + gas atomization + hot extrusion, respectively. The microstructures of the Al–5Ti–1B alloys prepared by two kinds of processes were studied, and the grain ...
LI Yang, GUO Xu-qiang, XU Lei, LI Chang-yun, LIU Xiao-fei   +4 more
doaj   +1 more source

Process induced degradation of carbamazepine during hot melt extrusion

British Journal of Pharmacy, 2023
The aim of this study was to evaluate hot melt extrudates of carbamazepine (CBZ) for presence of process induced degradation product iminostilbene (IMB) and quantifying using high performance liquid chromatography (HPLC). CBZ was used as model drug.
Sarbamangala Bose, Anant Paradkar, Adrian Kelly, Harika Magam   +3 more
doaj   +1 more source

The Development of Innovative Dosage Forms of the Fixed-Dose Combination of Active Pharmaceutical Ingredients

Pharmaceutics, 2022
The development of innovative forms of combination drugs is closely related to the invention of the multilayer tablet press, polymers for pharmaceutical applications, the hot-melt extrusion process, and 3D printing in the pharmaceutical industry. However,
Magdalena Janczura, Szymon Sip, Judyta Cielecka-Piontek   +2 more
doaj   +1 more source

MICROSTRUCTURE AND THERMAL STABILITY OF Al-Fe-X ALLOYS

Acta Metallurgica Slovaca, 2018
In this work, Al-11Fe, Al-7Fe-4Ni and Al-7Fe-4Cr (in wt. %) alloys were prepared by combination of casting and hot extrusion. Microstructures of as-cast alloys were composed of aluminium matrix with large and coarse intermetallics such as Al13Fe4 ...
Andrea Školáková, Petra Hanusová, Filip Průša, Pavel Salvetr, Pavel Novák, Dalibor Vojtěch   +5 more
doaj   +1 more source

Towards predicting the product quality in hot-melt extrusion: Pilot plant scale extrusion

International Journal of Pharmaceutics: X, 2021
Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality.
Josip Matić, Carolina Alva, Simone Eder, Kathrin Reusch, Amrit Paudel, Johannes Khinast   +5 more
doaj   +1 more source

Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions : the effect of wettability and dissolution [PDF]

, 2019
The aim of this study was to evaluate the choice of polymer and polymer level on the performance of the microstructure and wettability of hot-melt extruded solid dispersion of Glyburide (Gly) as a model drug.
Ward, Adam, Markl, Daniel, Kelly, Adrian L., Walton, Karl, Alshafiee, Maen, Blunt, Liam, Pagire, Sudhir K., Asare-Addo, Kofi, Paradkar, Anant, Conway, Barbara R., Aljammal, Mohammad K., Korde, Sachin   +11 more
core   +1 more source

Coupling Additive Manufacturing with Hot Melt Extrusion Technologies to Validate a Ventilator-Associated Pneumonia Mouse Model

Pharmaceutics, 2021
Additive manufacturing is widely used to produce highly complex structures. Moreover, this technology has proven its superiority in producing tools which can be used in different applications.
Bahaa Shaqour, Juliana Aizawa, Clara Guarch-Pérez, Żaneta Górecka, Lars Christophersen, Wim Martinet, Emilia Choińska, Martijn Riool, Bart Verleije, Koen Beyers, Claus Moser, Wojciech Święszkowski, Sebastian A. J. Zaat, Paul Cos   +13 more
doaj   +1 more source

Fabricação por extrusão de dispositivos poliméricos para liberação de antibiótico visando aplicações médicas [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência e Engenharia dos Materiais, Florianópolis, 2011O intento inicial deste trabalho fez-se na escolha de uma técnica de fabricação que ...
Zepon, Karine Modolon
core  

Innovative Processing of Compacted Waste Aluminum Alloy Powders via Controlled Remelting and Solidification

Advanced Engineering Materials, EarlyView.
This study demonstrates an efficient recycling route for out‐of‐spec AlSi10Mg atomized powders through compaction and arc remelting followed by suction casting. By correlating compaction load, cooling rate, and resulting microstructure, we show that intermediate pressures (50–80 kN) and rapid cooling refine dendrites, reduce porosity, and enhance ...
Mila Christy de Oliveira, Marcella Gaute Cavalcante Xavier, Abdoul‐Aziz Bogno, Piter Gargarella, José Eduardo Spinelli   +4 more
wiley   +1 more source