Results 41 to 50 of about 917,915 (175)
Разработка и регистрация лекарственных средств, 2022 Introduction. The low solubility of active pharmaceutical ingredients (APIs) in the physiological pH range of the intestinal tract can adversely affect their absorption and bioavailability.
S. A. Zolotov +4 more
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In-process rheometry as a PAT tool for hot melt extrusion [PDF]
Drug Development and Industrial Pharmacy, 2017 Real time measurement of melt rheology has been investigated as a Process Analytical Technology (PAT) to monitor hot melt extrusion of an Active Pharmaceutical Ingredient (API) in a polymer matrix. A developmental API was melt mixed with a commercial copolymer using a heated twin screw extruder at different API loadings and set temperatures.
Kelly, Adrian L. +7 more
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Journal of Manufacturing and Materials Processing, 2017 The melt-extrusion process is utilized in the pharmaceutical arena for the manufacturing of a variety of dosage forms and formulations, including solid dispersions.
Noel M. Gately, James E. Kennedy
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Pharmaceutics, 2021 Conventional oral dosage forms may not always be optimal especially for those patients suffering from dysphasia or difficulty swallowing. Development of suitable oral thin films (OTFs), therefore, can be an excellent alternative to conventional dosage ...
Jiaxiang Zhang +4 more
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Advanced Industrial and Engineering Polymer Research, 2021 Ultra-high molecular weight polyethylene (UHMWPE) possesses distinctive properties, but has an extremely low melt flow rate (MFR) of about zero, which makes it unsuitable for processing by standard methods for polymers.
S.V. Panin +6 more
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Hot Melt Extrusion Technology in Taste Masking
AAPS PharmSciTechAbstract Hot melt extrusion (HME) is a widely used method of taste masking in medication formulations, notably for bitter Active Pharmaceutical Ingredients (APIs). This continuous, solvent-free technique successfully wraps APIs within a polymer matrix, forming a barrier that considerably decreases bitterness perception.
Geetha Nayak, Usha Y. Nayak
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Hot-melt Extrusion Through Syringes [PDF]
, 2014 The use of solid dispersions to formulate poorly water soluble drugs is a growing field in the pharmaceutical sciences. Hot-melt extrusion is a common method for producing dispersions.
O'Connell, Sean Patrick
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A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products [PDF]
ISRN Pharmaceutics, 2012 Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide ...
Mohammed Maniruzzaman +3 more
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, 2022 The primary aim of this investigation was to develop a pharmaceutically suitable core-shell fixed-dose combination product for hypertensive dual therapy using hot-melt extrusion (HME) paired fused deposition modeling (FDM) 3D printing and direct ...
Suresh Bandari (13035424) +6 more
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Improving the Pharmaceutical Potential of Lycopene Using Hot-Melt Extrusion
Applied SciencesBackground: Lycopene is a powerful antioxidant, classified as a carotenoid. Numerous studies confirm its beneficial effects in both the prevention and treatment of various diseases. However, its therapeutic application is significantly limited due to its
Anna Kulawik +6 more
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