Results 21 to 30 of about 33,115 (300)

Optimizing Solvent Selection and Processing Conditions to Generate High Bulk-Density, Co-Precipitated Amorphous Dispersions of Posaconazole

Pharmaceutics, 2021
Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs), notable for its ability to enable the production of ASDs containing pharmaceuticals with thermal instability and limited solubility.
Derek Frank, Luke Schenck, Athanas Koynov, Yongchao Su, Yongjun Li, Narayan Variankaval   +5 more
doaj   +1 more source

Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance

Pharmaceutics, 2022
Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water solubilities, and they have gained great market success.
Qin Shi, Haibiao Chen, Yanan Wang, Ruoxun Wang, Jia Xu, Chen Zhang   +5 more
doaj   +1 more source

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs [PDF]

Advanced Pharmaceutical Bulletin, 2020
A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release
Avinash Ramrao Tekade, Jyoti Narayan Yadav   +1 more
doaj   +1 more source

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics, 2021
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li, Amanda K. P. Mann, Dan Zhang, Zhen Yang   +3 more
doaj   +1 more source

Polymer/Amorphous Salt Solid Dispersions of Ciprofloxacin [PDF]

Pharmaceutical Research, 2017
To improve the pharmaceutical properties of amorphous ciprofloxacin (CIP) succinate salts via formulation as polymer/amorphous salt solid dispersions (ASSDs).ASSDs consisting of an amorphous CIP/succinic acid 1:1 or 2:1 salt dispersed in PVP or Soluplus were produced by spray drying and ball milling.
Hanah Mesallati, Lidia Tajber
openaire   +4 more sources

The Stabilization of Amorphous Zopiclone in an Amorphous Solid Dispersion [PDF]

AAPS PharmSciTech, 2015
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quench-cooling of the melt. The solid dispersion was prepared by a
Milne, Marnus, Liebenberg, Wilna, Aucamp, Marique   +2 more
openaire   +4 more sources

Structural, electrical and catalytic properties of ion-implanted oxides [PDF]

, 1989
The potential application of ion implantation to modify the surfaces of ceramic materials is discussed. Changes in the chemical composition and microstructure result in important variations of the electrical and catalytic properties of ...
Burggraaf, A.J., Hassel, B.A. van
core   +8 more sources

Ternary Solid Dispersions: A Review of the Preparation, Characterization, Mechanism of Drug Release, and Physical Stability

Pharmaceutics, 2023
The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman, Eli Lailasari, Neng Vera Nurani, Ellen Nathania Yunita, Gracia Anastasya, Rizqa Nurul Aulia, Ira Novianty Lestari, Laila Subra, Diah Lia Aulifa   +8 more
doaj   +1 more source

Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants, 2021
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol.
Eun-Sol Ha, Du Hyung Choi, In-hwan Baek, Heejun Park, Min-Soo Kim   +4 more
doaj   +1 more source

Intermolecular interaction and solid state characterization of abietic acid/chitosan solid dispersions possessing antimicrobial and antioxidant properties [PDF]

, 2018
The aim of this work was to prepare and characterize solid dispersions of abietic acid (AB) and chitosan (CS) to investigate how formulation of the mixture may help in the battle against microbial colonization in different areas, such as the biomedical ...
Argent Richard, H., Cuzzucoli Crucitti, Valentina, Francolini, Iolanda, Garnett, Martin, Migneco, Luisa Maria, Piozzi, Antonella, Taresco, Vincenzo   +6 more
core   +1 more source