Results 21 to 30 of about 2,406 (250)

Polymer/Amorphous Salt Solid Dispersions of Ciprofloxacin [PDF]

Pharmaceutical Research, 2017
To improve the pharmaceutical properties of amorphous ciprofloxacin (CIP) succinate salts via formulation as polymer/amorphous salt solid dispersions (ASSDs).ASSDs consisting of an amorphous CIP/succinic acid 1:1 or 2:1 salt dispersed in PVP or Soluplus were produced by spray drying and ball milling.
Hanah Mesallati, Lidia Tajber
openaire   +4 more sources

Ternary Solid Dispersions: A Review of the Preparation, Characterization, Mechanism of Drug Release, and Physical Stability

Pharmaceutics, 2023
The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman, Eli Lailasari, Neng Vera Nurani, Ellen Nathania Yunita, Gracia Anastasya, Rizqa Nurul Aulia, Ira Novianty Lestari, Laila Subra, Diah Lia Aulifa   +8 more
doaj   +1 more source

Tailoring supersaturation from amorphous solid dispersions [PDF]

Journal of Controlled Release, 2018
The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected.
Na Li, Lynne S. Taylor
openaire   +2 more sources

Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants, 2021
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol.
Eun-Sol Ha, Du Hyung Choi, In-hwan Baek, Heejun Park, Min-Soo Kim   +4 more
doaj   +1 more source

Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

Pharmaceutics, 2018
In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and ...
Poovizhi Ponnammal, Parijat Kanaujia, Yin Yani, Wai Kiong Ng, Reginald B. H. Tan   +4 more
doaj   +1 more source

The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Frontiers in Molecular Biosciences, 2023
Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports ...
Haibin Wang, Yingying Lu, Haisong Yang, Deng-Guang Yu, Xuhua Lu   +4 more
doaj   +1 more source

Solid-state characterization of Felodipine–Soluplus amorphous solid dispersions [PDF]

Drug Development and Industrial Pharmacy, 2015
The aim of the current study is to develop amorphous solid dispersion (SD) via hot melt extrusion technology to improve the solubility of a water-insoluble compound, felodipine (FEL). The solubility was dramatically increased by preparation of amorphous SDs via hot-melt extrusion with an amphiphilic polymer, Soluplus® (SOL).
Jiannan, Lu, Kristina, Cuellar, Nathan I, Hammer, Seongbong, Jo, Andreas, Gryczke, Karl, Kolter, Nigel, Langley, Michael A, Repka   +7 more
openaire   +2 more sources

Compression-Induced Phase Transitions of Bicalutamide

Pharmaceutics, 2020
The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improves the dissolution characteristics of poorly soluble drugs.
Joanna Szafraniec-Szczęsny, Agata Antosik-Rogóż, Justyna Knapik-Kowalczuk, Mateusz Kurek, Ewa Szefer, Karolina Gawlak, Krzysztof Chmiel, Sebastian Peralta, Krzysztof Niwiński, Krzysztof Pielichowski, Marian Paluch, Renata Jachowicz   +11 more
doaj   +1 more source

Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

Pharmaceutics, 2023
Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral ...
Hannes Gierke, Susan Mouchantat, Sabine Berg, Michael Grimm, Stefan Hadlich, Marie-Luise Kromrey, Thomas Nolte, Teresa Pfrommer, Vincent Rönnpagel, Adrian Rump, Kerstin Schaefer, Ann-Cathrin Willmann, Werner Weitschies   +12 more
doaj   +1 more source

Expanding the processing space for amorphous solid dispersions

, 2023
Amorphous solid dispersions are an effective formulation approach to enhance the solubility of the increasing number of poorly water-soluble drugs in development pipelines.
Davis, Daniel Alan, Jr.
core   +1 more source