Results 21 to 30 of about 7,381 (260)
Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®
Molecules, 2015 Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Jinwen Liu +7 more
doaj +1 more source
Development and Physicochemical Characterization of Sirolimus Solid Dispersions Prepared by Solvent Evaporation Method [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties.
Shahram Emami +3 more
doaj +1 more source
Tailoring supersaturation from amorphous solid dispersions [PDF]
Journal of Controlled Release, 2018 The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected.
Na Li, Lynne S. Taylor
openaire +2 more sources
Pharmaceutics, 2019 The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be high among the scientific community.
Piyush Panini +4 more
doaj +1 more source
The solid-state modification for solubility enhancement of practically insoluble glimepiride: A systematic review [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Solubility is a crucial physicochemical property of pharmaceuticals that directly influences the absorption and bioavailability of drugs within the human body.
Fitrianti Darusman +3 more
doaj +1 more source
Pharmaceutics, 2020 This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system.
Sooho Yeo +4 more
doaj +1 more source
Modelling phase separation in amorphous solid dispersions [PDF]
Acta Biomaterialia, 2019 Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur. However, detailed partial differential equation non-equilibrium models that track the evolution of solid dispersions in time and space are ...
Meere Martin +2 more
openaire +5 more sources
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF KETOTIFEN BY SOLID DISPERSION TECHNIQUE [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2015 Ketotifen (KT) solid dispersions and physical mixtures were prepared with the objective of solubility and dissolution improvement using Hydroxypropyl-Beta-Cyclodextrin (HP-β-CD), Pluronic 127 (PF-127), Pluronic 68 (PF-68), Polyethylene glycol 6000 (PEG ...
Omnia Mahmoud +2 more
doaj +1 more source
Solid-state characterization of Felodipine–Soluplus amorphous solid dispersions [PDF]
Drug Development and Industrial Pharmacy, 2015 The aim of the current study is to develop amorphous solid dispersion (SD) via hot melt extrusion technology to improve the solubility of a water-insoluble compound, felodipine (FEL). The solubility was dramatically increased by preparation of amorphous SDs via hot-melt extrusion with an amphiphilic polymer, Soluplus® (SOL).
Jiannan, Lu +7 more
openaire +2 more sources
Use of Solid Dispersion Systems in Pharmacy
Конденсированные среды и межфазные границы, 2020 An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the ...
Sof ’ya Yu. Silaeva +6 more
doaj +1 more source