Results 221 to 230 of about 6,315,441 (313)

Targeting the ERK2 Signaling Pathway With Frog Skin-Derived Bioactive Peptides: Insights From Molecular Modeling, Molecular Dynamics, and Physicochemical Features. [PDF]

ChemistryOpen
Almansour NM, Abdelhamid MMH, Alali Z, Ibrahim MAA.   +3 more
europepmc   +1 more source

Of (computers and cells) mice and men: Integration of Simulations and Experiments in biomedical sciences.

, 2015
LAURINI, ERIK, POSOCCO, PAOLA, FERMEGLIA, MAURIZIO, PRICL, SABRINA   +3 more
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Oil Characterization, Molecular Modeling and Process Simulation in Petroleum Research and Industry, Opportunities, Challenges and Perspectives. [PDF]

Molecules
Vasilev S, Stratiev D, Shishkova I, Dinkov R, Yordanov D, Abdellatief TMM, Sotirov S, Sotirova E, Dimitrov A, Georgieva V, Pencheva T, Atanassov K, Nikolova R.   +12 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Dual inhibitors of CDK2 and TRKA kinases: design, synthesis, antiproliferative activity and molecular modeling of novel pyrazolopyrimidine derivatives. [PDF]

RSC Adv
Attia MH, Lasheen DS, Samir N, Taher AT, Abdel-Aziz HA, Abou El Ella DA.   +5 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Structural Characterization, Toxicity Assessment and Molecular Modeling of Forced Degradation Products of Siponimod. [PDF]

Int J Mol Sci
Liang Y, Zhang T, Zhang D, Jin B, Ma C.
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Synthesis, anti-proliferative evaluation, DFT, <i>in silico</i> ADME and molecular modeling studies of novel imidazolones as potential EGFR inhibitors. [PDF]

RSC Adv
Hekal MH, Abdel-Megid M, Salem ME, Alrashdi S, Alzahrani AYA, Abu El-Azm FSM.   +5 more
europepmc   +1 more source