Results 31 to 40 of about 551,885 (316)

Ribose and Non-Ribose A2A Adenosine Receptor Agonists: Do They Share the Same Receptor Recognition Mechanism?

Biomedicines, 2022
Adenosine receptors have been a promising class of targets for the development of new therapies for several diseases. In recent years, a renewed interest in this field has risen, thanks to the implementation of a novel class of agonists that lack the ...
Giovanni Bolcato, Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Molecular footprints of the Holocene retreat of dwarf birch in Britain [PDF]

, 2014
© 2014 The Authors. Molecular Ecology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original ...
Bodles, WJA, Borrell, JS, Kuttapitiya, A, Richard A. Nichols, Wang, N, Nian Wang, William J A. Bodles, Anasuya Kuttapitiya, Richard J A. Buggs, Buggs, RJA, James S. Borrell, Nichols, RA   +11 more
core   +1 more source

Molecular modeling approach to predict a binding mode for the complex methotrexate-carboxypeptidase G(2) [PDF]

, 2011
Carboxypeptidase G(2) (CPG(2)) is a zinc-metalloenzyme employed in a range of cancer chemotherapy strategies by activating selectively nontoxic prodrugs into cytotoxic drugs in tumor as well as in the treatment of intoxication caused by high-doses of the
Kerly Fernanda Mesquita Pasqualoto, Elizabeth Igne Ferreira, Ferreira, Elizabeth Igne, Mesquita Pasqualoto, Kerly Fernanda, Daniela Gonçales Rando, Turra, Kely Medeiros, Kely Medeiros Turra, Rando, Daniela Goncales [UNIFESP]   +7 more
core   +1 more source

Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops

Nature Communications, 2023
Antibody derivatives have sought to recapitulate the antigen binding properties of antibodies, but with improved biophysical attributes convenient for therapeutic, diagnostic and research applications.
Jorge Roel-Touris, Marta Nadal, Enrique Marcos   +2 more
doaj   +1 more source

Aminoglycoside induced nephrotoxicity: molecular modeling studies of calreticulin-gentamicin complex [PDF]

, 2011
Gentamicin is a member of aminoglycoside group of broad spectrum antibiotics. It impairs protein synthesis by binding to A site of the 30S subunit of bacterial ribosomes. One of the main side effects of this drug is nephrotoxicity.
Gururao Hariprasad, Rani, Komal, Alagiri Srinivasan, Hariprasad, Gururao, Kumar, Manoj, Kaur, Punit, Manoj Kumar, Komal Rani, Srinivasan, Alagiri, Punit Kaur   +9 more
core   +1 more source

From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Since the outbreak of the COVID-19 pandemic in December 2019, the SARS-CoV-2 genome has undergone several mutations. The emergence of such variants has resulted in multiple pandemic waves, contributing to sustaining to date the number of infections ...
Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +3 more
doaj   +1 more source

Molecular psychiatry of zebrafish [PDF]

, 2014
Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry.
Parker, M. O., Stewart, AM, Stewart, A. M., Stewart, A. M ., Ullmann, J. F. P., Norton, WHJ, Ullmann, JFP, Kalueff, A. V., Gerlai, R, Norton, W. H. J., Brennan, C. H., Gerlai, R., Brennan, CH, Parker, MO, Kalueff, AV   +14 more
core   +2 more sources

Tuning the balance between dispersion and entropy to design temperature-responsive flexible metal-organic frameworks

Nature Communications, 2018
Rational design of metal organic frameworks (MOFs) with shape-memory nanopores is a formidable challenge. Here the authors use an accurate theoretical approach to design thermo-responsive MOFs based on a balance of van der Waals and entropy contributions.
J. Wieme, K. Lejaeghere, G. Kresse, V. Van Speybroeck   +3 more
doaj   +1 more source

3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases

Biomedicines, 2022
The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race.
Shirley Pei Shan Chia, Sharleen Li Ying Kong, Jeremy Kah Sheng Pang, Boon-Seng Soh   +3 more
doaj   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source