Results 61 to 70 of about 163,670 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evaluating the purification efficiency of Moroccan waste stabilization ponds’ systems: challenges and future prospects [PDF]

The Holistic Approach to Environment
Lagoon wastewater treatment systems, introduced in 1970, have become a preferred economic solution in Morocco due to favourable climatic and economic conditions. However, these facilities often face performance problems, particularly related to excessive
Marouan Akdim, Latifa Tajounte, Abdelmajid Achkir, Mohammed El Mahi, Mokhtar Jaait, El Mostapha Lotfi   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Hard-sphere/pseudo-particle modelling (HS-PPM) for efficient and scalable molecular simulation of dilute gaseous flow and transport

, 2016
Continuum methods are not accurate enough for flows at high Knudsen numbers, whereas rigorous molecular dynamics ( MD) methods are too costly for simulations at practical dimensions.
Shen, Guofei, Li, Jinghai, Zhang, Chenglong, Ge, Wei, Li, Chengxiang   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Direct determination of amorphous number density from the reduced pair distribution function

MethodsX, 2019
The inference of amorphous bulk density, while straightforward for nonporous, soluble materials, may present a formidable challenge in some of the most important classes of industrial applications, involving melts, porous solids, and non-soluble organic ...
Georgios S.E. Antipas, Konstantinos T. Karalis   +1 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Homology Modelling, Molecular Docking and Molecular Dynamics Simulation Studies of CALMH1 against Secondary Metabolites of Bauhinia variegata to Treat Alzheimer’s Disease

, 2022
Calcium homeostasis modulator 1 (CALHM1) is a protein responsible for causing Alzheimer’s disease. In the absence of an experimentally designed protein molecule, homology modelling was performed.
Alsagaby, Suliman A., Niraj Kumar Jha, Khare, Noopur, Chiara Villa, Albadrani, Hind Muteb, Danish Iqbal, Saurabh Kumar Jha, Syed Mohd Danish Rizvi, Maheshwari, Sanjiv Kumar, Jha, Niraj Kumar, Wael Alturaiki, Zia, Qamar, Villa, Chiara, Jha, Abhimanyu Kumar, Rizvi, Syed Mohd Danish, Alturaiki, Wael, Hind Muteb Albadrani, Iqbal, Danish, Abhimanyu Kumar Jha, Noopur Khare, Sanjiv Kumar Maheshwari, Jha, Saurabh Kumar, Suliman A. Alsagaby, Qamar Zia   +23 more
core   +1 more source

Isomorphs in Model Molecular Liquids

The Journal of Physical Chemistry B, 2012
20 ...
Ingebrigtsen, Trond, Schrøder, Thomas, Dyre, J. C.; id_orcid 0000-0002-0770-5690   +2 more
openaire   +4 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source