Results 111 to 120 of about 319,211 (210)

A molecular motor from lignocellulose. [PDF]

Green Chem, 2022
Freese T, Fridrich B, Crespi S, Lubbe AS, Barta K, Feringa BL.   +5 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Molecular Motor Myosin 5B and Its Folding Chaperone UNC45A Are Decreased in Colorectal Cancer. [PDF]

Cell Mol Gastroenterol Hepatol
Dooley SA, Stubler R, Maity PP, Múnera J, Kourtidis A, Engevik MA, Engevik AC.   +6 more
europepmc   +1 more source

Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor. [PDF]

Proc Natl Acad Sci U S A, 2021
Ganichkin OM, Vancraenenbroeck R, Rosenblum G, Hofmann H, Mikhailov AS, Daumke O, Noel JK.   +6 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Coupling Rotary Motion to Helicene Inversion within a Molecular Motor. [PDF]

Angew Chem Int Ed Engl
Gisbert Y, Ovalle M, Stindt CN, Costil R, Feringa BL.   +4 more
europepmc   +1 more source

Steric Effects on the Thermal Processes of Hemithioindigo Based Molecular Motor Rotation. [PDF]

Chemistry, 2021
Huber LA, Thumser S, Grill K, Voßiek D, Bach NN, Mayer P, Dube H.   +6 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Directionality Reversal and Shift of Rotational Axis in a Hemithioindigo Macrocyclic Molecular Motor. [PDF]

J Am Chem Soc
Reißenweber L, Uhl E, Hampel F, Mayer P, Dube H.   +4 more
europepmc   +1 more source

Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory. [PDF]

Mol Brain, 2021
Joseph NF, Zucca A, Wingfield JL, Espadas I, Page D, Puthanveettil SV.   +5 more
europepmc   +1 more source