Results 51 to 60 of about 319,211 (210)
Excited-State Dynamics Simulations of a Light-Driven Molecular Motor in Solution. [PDF]
J Phys Chem A, 2023 Wen J, Mai S, González L.
europepmc +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Synthetic molecular motor activates drug delivery from polymersomes. [PDF]
Proc Natl Acad Sci U S A, 2023 Guinart A +8 more
europepmc +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Defining Unidirectional Motions and Structural Reconfiguration in a Macrocyclic Molecular Motor. [PDF]
J Am Chem Soc, 2023 Regen-Pregizer BL, Dube H.
europepmc +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Correction: A visible-light-driven molecular motor based on barbituric acid. [PDF]
Chem Sci, 2023 Kuntze K +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Model-based trajectory classification of anchored molecular motor-biopolymer interactions. [PDF]
Biophys Rep (N Y), 2023 Linehan JB +4 more
europepmc +1 more source