Results 31 to 40 of about 358,120 (301)

Effect of the Neck Linker on Processive Stepping of Kinesin Motor

Biophysica, 2023
Kinesin motor protein, which is composed of two catalytic domains connected together by a long coiled-coil stalk via two flexible neck linkers (NLs), can step processively on a microtubule towards the plus end by hydrolyzing adenosine triphosphate (ATP ...
Ping Xie
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A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation

eLife, 2015
The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation.
Binyam Mogessie, Daniel Roth, Zainab Rahil, Anne Straube   +3 more
doaj   +1 more source

Robustness in an Ultrasensitive Motor

mBio, 2020
In Escherichia coli, the chemotaxis response regulator CheY-P binds to FliM, a component of the switch complex at the base of the bacterial flagellar motor, to modulate the direction of motor rotation.
Guangzhe Liu, Antai Tao, Rongjing Zhang, Junhua Yuan   +3 more
doaj   +1 more source

Transient pauses of the bacterial flagellar motor at low load

New Journal of Physics, 2016
The bacterial flagellar motor (BFM) is the molecular machine responsible for the swimming and chemotaxis of many species of motile bacteria. The BFM is bidirectional, and changes in the rotation direction of the motor are essential for chemotaxis. It has
A L Nord, F Pedaci, R M Berry
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The human cytoplasmic dynein interactome reveals novel activators of motility

eLife, 2017
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson   +8 more
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Decoding the molecular mechanism underpinning motor neuron degeneration in ALS

, 2023
reservedMotor neuron degeneration is one of the main feature of different neuromuscular diseases, including Amyotrophic Lateral Sclerosis (ALS). The molecular mechanism underpinning motor neuron degeneration has not been well understood yet, hampering ...
SARTORE, LUIGI
core  

Small steps and giant leaps

eLife, 2015
A study of kinesin-1 has shed new light on how motor proteins are able to move along microtubules inside cells.
Bram Prevo, Erwin JG Peterman
doaj   +1 more source

Spirochete Flagella and Motility

Biomolecules, 2020
Spirochetes can be distinguished from other flagellated bacteria by their long, thin, spiral (or wavy) cell bodies and endoflagella that reside within the periplasmic space, designated as periplasmic flagella (PFs).
Shuichi Nakamura
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Electrostatically biased binding of kinesin to microtubules [PDF]

, 2011
The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the ...
Zheng Wenjun, Zheng, Wenjun, Grant, Barry J, McCammon, J. Andrew, Grant, Barry J., Cross, Robert A., Gary Huber, McCammon, J Andrew, Dlugosz, Maciej, Maria Alonso, Huber, Gary, McCammon J. Andrew, Maciej Dlugosz, Barry J. Grant, J Andrew McCammon, Robert A. Cross, Gheorghe, Dana M, Cross, R. A., M. Gheorghe Dana, Wenjun Zheng, Barry J Grant, Alonso, M. (Maria), Alonso Maria, Robert A Cross, J. Andrew McCammon, Dana M Gheorghe, Dana M. Gheorghe, Cross Robert A., Alonso, Maria, Grant Barry J., Huber Gary, Cross, Robert A, Gheorghe, Dana M., Dlugosz Maciej   +33 more
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How Does F1-ATPase Generate Torque?: Analysis From Cryo-Electron Microscopy and Rotational Catalysis of Thermophilic F1

Frontiers in Microbiology, 2022
The F1-ATPase is a rotary motor fueled by ATP hydrolysis. Its rotational dynamics have been well characterized using single-molecule rotation assays. While F1-ATPases from various species have been studied using rotation assays, the standard model for ...
Hiroyuki Noji, Hiroshi Ueno
doaj   +1 more source