Results 11 to 20 of about 4,509,513 (302)

Prospects for single-molecule electrostatic detection in molecular motor gliding motility assays

New Journal of Physics, 2021
Molecular motor gliding motility assays based on myosin/actin or kinesin/microtubules are of interest for nanotechnology applications ranging from cargo-trafficking in lab-on-a-chip devices to novel biocomputation strategies.
M Sanchez Miranda, R Lyttleton, P H Siu, S Diez, H Linke, A P Micolich   +5 more
doaj   +1 more source

Biochemical and Biophysical Characterization of the dsDNA Packaging Motor from the Lactococcus lactis Bacteriophage Asccphi28

Viruses, 2020
Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome ...
Emilio Reyes-Aldrete, Erik A. Dill, Cecile Bussetta, Michal R. Szymanski, Geoffrey Diemer, Priyank Maindola, Mark A. White, Wlodzimierz M. Bujalowski, Kyung H. Choi, Marc C. Morais   +9 more
doaj   +1 more source

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

eLife, 2014
Microtubule-based transport by the kinesin motors, powered by ATP hydrolysis, is essential for a wide range of vital processes in eukaryotes. We obtained insight into this process by developing atomic models for no-nucleotide and ATP states of the ...
Zhiguo Shang, Kaifeng Zhou, Chen Xu, Roseann Csencsits, Jared C Cochran, Charles V Sindelar   +5 more
doaj   +1 more source

Rotary mechanism of V/A-ATPases—how is ATP hydrolysis converted into a mechanical step rotation in rotary ATPases?

Frontiers in Molecular Biosciences, 2023
V/A-ATPase is a rotary molecular motor protein that produces ATP through the rotation of its central rotor. The soluble part of this protein, the V1 domain, rotates upon ATP hydrolysis.
Ken Yokoyama
doaj   +1 more source

Multiscale Modeling of Skeletal Muscle Active Contraction in Relation to Mechanochemical Coupling of Molecular Motors

Micromachines, 2015
In this work, a mathematical model was developed to relate the mechanochemical characterizations of molecular motors with the macroscopic manifestation of muscle contraction.
Jiangcheng Chen, Xiaodong Zhang, Shengmao Lin, He Wang, Linxia Gu   +4 more
doaj   +1 more source

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S, Gross, Steven P, Major, Jennifer, Moores, Carolyn, Jung, Y., Goulet, Adeline, Rosenfeld, Steven, Moores, Carolyn A, Major, J., Moores, Carolyn A., Jun, Yonggun, Gross, Steven, Rosenfeld, S.S., Grossmann, S.P.   +13 more
core   +1 more source

Active mechanical threading by a molecular motor [PDF]

, 2021
Molecular motors transform external energy input into directional motions and offer exquisite precision for nano-scale manipulations. In order to make full use of molecular motor capacities, their directional motions need to be transmitted and used for ...
Henry, Dube, Nicolai N., Bach, Harald, Maid, Verena, Josef   +3 more
core   +2 more sources

Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

eLife, 2018
The light chains (KLCs) of the heterotetrameric microtubule motor kinesin-1, that bind to cargo adaptor proteins and regulate its activity, have a capacity to recognize short peptides via their tetratricopeptide repeat domains (KLCTPR). Here, using X-ray
Stefano Pernigo, Magda S Chegkazi, Yan Y Yip, Conor Treacy, Giulia Glorani, Kjetil Hansen, Argyris Politis, Soi Bui, Mark P Dodding, Roberto A Steiner   +9 more
doaj   +1 more source

Langevin approach to the Porto system

Entropy, 2004
: M. Porto (Phys. Rev. E 63 (2001) 030102) suggested a system consisting of Coulomb interacting particles, forming a linear track and a rotor, and working as a molecular motor. Newton equations with damping for the rotor coordinate on the track x, with a
Vladislav Cápek, Jirí Bok
doaj   +1 more source

A programmable optical angle clamp for rotary molecular motors [PDF]

, 2007
Optical tweezers are widely used for experimental investigation of linear molecular motors. The rates and force dependence of steps in the mechanochemical cycle of linear motors have been probed giving detailed insight into motor mechanisms. With similar
Berry, RM, Futai, Masamitsu, Bai, Fan, Futai, M, Bilyard, Thomas, Pilizota, T, Berry, Richard, Bilyard, T, Bai, F, Hosokawa, H, Hosokawa, Hiroyuki, Pilizota, Teuta, Berry, Richard M., Berry, Richard Michael   +13 more
core   +1 more source