Results 11 to 20 of about 706,415 (288)

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

open access: yeseLife, 2014
Microtubule-based transport by the kinesin motors, powered by ATP hydrolysis, is essential for a wide range of vital processes in eukaryotes. We obtained insight into this process by developing atomic models for no-nucleotide and ATP states of the ...
Zhiguo Shang   +5 more
doaj   +1 more source

Rotary mechanism of V/A-ATPases—how is ATP hydrolysis converted into a mechanical step rotation in rotary ATPases?

open access: yesFrontiers in Molecular Biosciences, 2023
V/A-ATPase is a rotary molecular motor protein that produces ATP through the rotation of its central rotor. The soluble part of this protein, the V1 domain, rotates upon ATP hydrolysis.
Ken Yokoyama
doaj   +1 more source

Multiscale Modeling of Skeletal Muscle Active Contraction in Relation to Mechanochemical Coupling of Molecular Motors

open access: yesMicromachines, 2015
In this work, a mathematical model was developed to relate the mechanochemical characterizations of molecular motors with the macroscopic manifestation of muscle contraction.
Jiangcheng Chen   +4 more
doaj   +1 more source

Molecular Motors

open access: yesMolecular Biology of the Cell, 2013
Synthetische moleculaire motoren zijn moleculaire motoren die kunnen roteren door invloed van een energetische stimulans; bij lichtaangedreven moleculaire rotoren is dit licht. Dit onderzoek richtte zich op synthetische lichtaangedreven éénrichtingsroterende moleculaire motoren gebaseerd op overpopulatie van alkenen die fotoisomerisaties ondergaan ...
Trybus, Kathleen M.   +1 more
  +5 more sources

Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

open access: yeseLife, 2018
The light chains (KLCs) of the heterotetrameric microtubule motor kinesin-1, that bind to cargo adaptor proteins and regulate its activity, have a capacity to recognize short peptides via their tetratricopeptide repeat domains (KLCTPR). Here, using X-ray
Stefano Pernigo   +9 more
doaj   +1 more source

Langevin approach to the Porto system

open access: yesEntropy, 2004
: M. Porto (Phys. Rev. E 63 (2001) 030102) suggested a system consisting of Coulomb interacting particles, forming a linear track and a rotor, and working as a molecular motor. Newton equations with damping for the rotor coordinate on the track x, with a
Vladislav Cápek, Jirí Bok
doaj   +1 more source

From aggressive driving to molecular motor traffic [PDF]

open access: yes, 2006
Motivated by recent experimental results for the step sizes of dynein motor proteins, we develope a cellular automata model for intra-cellular traffic of dynein motors incorporating special features of the hindrance-dependent step size of the individual ...
Chowdhury, Debashish   +2 more
core   +4 more sources

Robust quantization of a molecular motor motion in a stochastic environment [PDF]

open access: yes, 2009
We explore quantization of the response of a molecular motor to periodic modulation of control parameters. We formulate the Pumping-Quantization Theorem (PQT) that identifies the conditions for robust integer quantized behavior of a periodically driven ...
Chernyak, V. Y., Sinitsyn, N. A.
core   +3 more sources

External Stresses Affect Gonococcal Type 4 Pilus Dynamics

open access: yesFrontiers in Microbiology, 2022
Bacterial type 4 pili (T4P) are extracellular polymers that serve both as adhesins and molecular motors. Functionally, they are involved in adhesion, colony formation, twitching motility, and horizontal gene transfer.
Sebastian Kraus-Römer   +5 more
doaj   +1 more source

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

open access: yes, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline   +5 more
core   +3 more sources

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