Results 121 to 130 of about 11,611,859 (368)
Acta Pharmacologica Sinica, 2015 Aim:Guizhi-Shaoyao-Zhimu decoction (GSZ), a traditional Chinese medicine (TCM) herbal formula, has been shown effective in the treatment of diabetic peripheral neuropathy (DPN).
Ning Zhao +8 more
semanticscholar +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
, 2008 Molecular codes translate information written in one type of molecules into another molecular language. We introduce a simple model that treats molecular codes as noisy information channels.
Tlusty, Tsvi
core +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Machine Learning Molecular Dynamics for the Simulation of Infrared Spectra
, 2017 Machine learning has emerged as an invaluable tool in many research areas. In the present work, we harness this power to predict highly accurate molecular infrared spectra with unprecedented computational efficiency. To account for vibrational anharmonic
Behler, Jörg +2 more
core +1 more source
Molecular network of HCC aggressiveness
Oncoscience, 2015 Hepatocellular carcinoma (HCC) is one of the main causes of cancer-related mortality worldwide. It has a poor prognosis due to aggressive phenotype, and limited and insufficient treatment options. In HCCs, acquisition of epithelial mesenchymal transition (EMT) features may account for tumor aggressiveness and chemo-resistance. Many of G protein-coupled
Sang Geon Kim +2 more
openaire +3 more sources
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
, 2015 We perform off-lattice, canonical ensemble molecular dynamics simulations of the self-assembly of long segmented copolymers consisting of alternating, tunably attractive and hydrophobic {\em binder} domains, connected by hydrophilic {\em linker} chains ...
Mortazavi, Hamed, Storm, Cornelis
core
Unifying Evolutionary and Network Dynamics
, 2007 Many important real-world networks manifest "small-world" properties such as scale-free degree distributions, small diameters, and clustering. The most common model of growth for these networks is "preferential attachment", where nodes acquire new links ...
Gasser, Les, Swarup, Samarth
core +1 more source
Beverage Plant ResearchCoffee diterpenes are a class of characteristic components in coffee, which have potential biological activities including the prevention of cancer, obesity, diabetes, and other diseases.
Guilin Hu +4 more
doaj +1 more source