Results 131 to 140 of about 1,062,909 (310)

Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma [PDF]

, 2005
Cancer can be defined as a deregulation or hyperactivity in the ongoing network of intracellular and extracellular signaling events. Reverse phase protein microarray technology may offer a new opportunity to measure and profile these signaling pathways ...
Runa Speer, Wulfkuhle, Julia, Lance A. Liotta, Liotta, Lance A., Elaine W. Kay, Emanuel F. Petricoin, Valerie S. Calvert, Aquino, Joy, Fisherman, David, Yiling Lu, Gordon B. Mills, Sheehan, Katherine M., Araujo, Robyn P., Speer, Runa, Robyn Araujo, Mills, Gordon B., Calvert, Valerie S., Joy Aquino, Lu, Yiling, Kay, Elaine W., Katherine M. Sheehan, David Fishman, Espina, Virginia, Petricoin III, Emanuel F., Virginia Espina, Julia D. Wulfkuhle   +25 more
core   +1 more source

Chemical Constituent Analysis of Moringa oleifera Leaves Based on High-Performance Liquid Chromatography-Quadrupole Time-of-Flight Tandem Mass Spectrometry/Mass Spectrometry Combined with Molecular Network Technology

World Journal of Traditional Chinese Medicine
Objective: Moringa oleifera Lam. (M. oleifera) leaves are from a high-economic-value crop and exhibit multiple pharmacological effects, such as hypolipidemic and hypoglycemic activities. However, the studies on the pharmacological basis of M.
Ya-Nan Song, Zhe Jia, Hong-Jun Yang, Yan-Ping Liu, Lin Yan, Javed Iqbal, Yun Wang, Cun Zhang   +7 more
doaj   +1 more source

Molecular communication networks with general molecular circuit receivers [PDF]

Proceedings of ACM The First Annual International Conference on Nanoscale Computing and Communication, 2014
In a molecular communication network, transmitters may encode information in concentration or frequency of signalling molecules. When the signalling molecules reach the receivers, they react, via a set of chemical reactions or a molecular circuit, to produce output molecules. The counts of output molecules over time is the output signal of the receiver.
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

JigCell Model Connector: Building Large Molecular Network Models from Components [PDF]

, 2017
The ever-growing size and complexity of molecular network models makes them difficult to construct and understand. Modifying a model that consists of tens of reactions is no easy task.
Jones, Thomas Carroll Jr.
core  

Functional dissection of the TBK1 molecular network. [PDF]

, 2011
TANK-binding kinase 1 (TBK1) and inducible IκB-kinase (IKK-i) are central regulators of type-I interferon induction. They are associated with three adaptor proteins called TANK, Sintbad (or TBKBP1) and NAP1 (or TBKBP2, AZI2) whose functional relationship
Cristina Sugar, Tilmann Bürckstümmer, Evelyn Dixit, Maria W. Górna, Adriana Goncalves, Tiina Berg, Keiryn L. Bennett, Robert Kralovics, Keiryn L Bennett, Maria W Górna, Giulio Superti-Furga, Evren Karayel, Ruth Scheicher, Melanie Planyavsky, Jacques Colinge, Alexey Stukalov   +15 more
core   +1 more source

Proteome-wide prediction of the mode of inheritance and molecular mechanisms underlying genetic diseases using structural interactomics

iScience
Summary: Genetic diseases can be classified according to their modes of inheritance and their underlying molecular mechanisms. Autosomal dominant disorders often result from DNA variants that cause loss-of-function, gain-of-function, or dominant-negative
Ali Saadat, Jacques Fellay
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Molecular Networks Regulating Meristem Homeostasis [PDF]

Molecular Plant, 2018
International ...
openaire   +4 more sources