Results 151 to 160 of about 1,062,909 (310)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Sox9 and the Molecular Network Regulating Neural Crest Cell Motility [PDF]
, 2014 The neural crest (NC) is one of the most characterized and accessible experimental systems to study the molecular regulation of cell migration. Our recent studies showed that phosphorylation of Sox9 is sufficient and required for NC delamination in the ...
Ho, CKY +8 more
core
Erosion of the molecular network in the amorphous layers of polyethylene upon high- strain deformation [PDF]
, 2016 International audienceSamples of linear polyethylene, neat and crosslinked by irradiation with electron beam, were subjected to heavy plastic deformation by plane-strain compression up to the true strain exceeding 2 (deformation ratio λ > 8) at room ...
Gadzinowska, Krystyna +3 more
core +1 more source
Entropy Bounds for Hierarchical Molecular Networks
PLoS ONE, 2008 In this paper we derive entropy bounds for hierarchical networks. More precisely, starting from a recently introduced measure to determine the topological entropy of non-hierarchical networks, we provide bounds for estimating the entropy of hierarchical graphs.
Dehmer, M. +2 more
openaire +7 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Rapid Identification of Constituents of Aronia Melanocarpa (Michx.) Elliott Fruit by UPLC-Qrbitrap-MS/MS and GNPS Molecular Network [PDF]
The fruits of Aronia melanocarpa (Michx.) Elliot have high nutritional value and medicinal value. This fruit is rich in flavonoids, anthocyanins and anthocyanins and presents good biological activity and pharmacological effects in antioxidant, anti-aging,
Xin HUANG +4 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source