Results 1 to 10 of about 93,547 (172)

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study [PDF]

Clinical and Translational Science, 2020
Determining factors that contribute to interindividual and intra‐individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alan K. Jarmusch, Alison Vrbanac, Jeremiah D. Momper, Joseph D. Ma, Maher Alhaja, Marlon Liyanage, Rob Knight, Pieter C. Dorrestein, Shirley M. Tsunoda   +8 more
doaj   +2 more sources

Structure characterization with NMR molecular networking [PDF]

Communications Chemistry
Nuclear Magnetic Resonance (NMR) is among the most widely used techniques for structure determination, yet automated workflows remain underdeveloped compared to mass spectrometry.
Cailum M. K. Stienstra, Jaegun Song, David Healey, Gennady Voronov, Eric Gardner, Abhishek Patel, Venkat Macherla, Christoph A. Krettler, Tobias Kind, Pieter C. Dorrestein, Daniel Domingo-Fernández   +10 more
doaj   +2 more sources

Metabolomic Profiling of Iris palaestina via Molecular Networking and Its Anti-Diabetic Potential [PDF]

Molecules
The Iris genus is known for its large blooms and significant conservation value, as well as its horticultural appeal. There are over 300 species of irises, which are widely distributed across the northern temperate zone.
Ayman Turk, Khodr Addam, Bang Yeon Hwang, Mi Kyeong Lee   +3 more
doaj   +2 more sources

Molecular networks in Network Medicine: Development and applications [PDF]

WIREs Systems Biology and Medicine, 2020
AbstractNetwork Medicine applies network science approaches to investigate disease pathogenesis. Many different analytical methods have been used to infer relevant molecular networks, including protein–protein interaction networks, correlation‐based networks, gene regulatory networks, and Bayesian networks.
Silverman, Edwin K., Schmidt, Harald H. H. W., Anastasiadou, Eleni, Altucci, Lucia, Angelini, Marco, Badimon, Lina, Balligand, Jean‐Luc, Benincasa, Giuditta, Capasso, Giovambattista, Conte, Federica, Di Costanzo, Antonella, Farina, Lorenzo, Fiscon, Giulia, Gatto, Laurent, Gentili, Michele, Loscalzo, Joseph, Marchese, Cinzia, Napoli, Claudio, Paci, Paola, Petti, Manuela, Quackenbush, John, Tieri, Paolo, Viggiano, Davide, Vilahur, Gemma, Glass, Kimberly, Baumbach, Jan   +25 more
openaire   +9 more sources

Optimization of LC-MS² Data Acquisition Parameters for Molecular Networking Applied to Marine Natural Products

Metabolites, 2022
Since the introduction of the online open-source GNPS, molecular networking has quickly become a widely applied tool in the field of natural products chemistry, with applications from dereplication, genome mining, metabolomics, and visualization of ...
Sam Afoullouss, Agata Balsam, A. Louise Allcock, Olivier P. Thomas   +3 more
doaj   +1 more source

An ACE2/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria

Redox Biology, 2021
ACE2 plays a pivotal role in the balance between the pro-oxidative pro-inflammatory and the anti-oxidative anti-inflammatory arms of the renin-angiotensin system. Furthermore, ACE2 is the entry receptor for SARS-CoV-2.
Rita Valenzuela, Ana I. Rodriguez-Perez, Maria A. Costa-Besada, Rafael Rivas-Santisteban, Pablo Garrido-Gil, Andrea Lopez-Lopez, Gemma Navarro, Jose L. Lanciego, Rafael Franco, Jose L. Labandeira-Garcia   +9 more
doaj   +1 more source

P2X7 Receptor Upregulation in Huntington’s Disease Brains

Frontiers in Molecular Neuroscience, 2020
Huntington’s disease (HD) is a fatal degenerative disorder affecting the nervous system. It is characterized by motor, cognitive, and psychiatric dysfunctions, with a late onset and an autosomal dominant pattern of inheritance.
Ivana Ollà, Ivana Ollà, María Santos-Galindo, María Santos-Galindo, Ainara Elorza, Ainara Elorza, José J. Lucas, José J. Lucas   +7 more
doaj   +1 more source

Functional Molecular Ecological Networks [PDF]

mBio, 2010
ABSTRACT Biodiversity and its responses to environmental changes are central issues in ecology and for society. Almost all microbial biodiversity research focuses on “species” richness and abundance but not on their interactions. Although a network approach is powerful in describing ecological interactions among species, defining
Jizhong Zhou, Ye Deng, Feng Luo, Zhili He, Qichao Tu, Xiaoyang Zhi   +5 more
openaire   +3 more sources

Molecular ecological network analyses [PDF]

BMC Bioinformatics, 2012
AbstractBackgroundUnderstanding the interaction among different species within a community and their responses to environmental changes is a central goal in ecology. However, defining the network structure in a microbial community is very challenging due to their extremely high diversity and as-yet uncultivated status.
Deng Ye, Jiang Yi-Huei, Yang Yunfeng, He Zhili, Luo Feng, Zhou Jizhong   +5 more
openaire   +3 more sources

VOLTA: adVanced mOLecular neTwork Analysis

Bioinformatics, 2021
Abstract Motivation Network analysis is a powerful approach to investigate biological systems. It is often applied to study gene co-expression patterns derived from transcriptomics experiments.
Alisa Pavel, Antonio Federico, Giusy del Giudice, Angela Serra, Dario Greco   +4 more
openaire   +6 more sources