Results 61 to 70 of about 93,666 (291)
Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids [PDF]
, 2019 A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate with highly adapted and ...
Mazmanian, Sarkis +2 more
core
Fast Detection of Two Smenamide Family Members Using Molecular Networking. [PDF]
, 2019 Caribbean sponges of the genus Smenospongia are a prolific source of chlorinated secondary metabolites. The use of molecular networking as a powerful dereplication tool revealed in the metabolome of S.
Alessia Caso +6 more
core +1 more source
Graph neural networks accelerated molecular dynamics
The Journal of Chemical Physics, 2022 Molecular Dynamics (MD) simulation is a powerful tool for understanding the dynamics and structure of matter. Since the resolution of MD is atomic-scale, achieving long timescale simulations with femtosecond integration is very expensive. In each MD step, numerous iterative computations are performed to calculate energy based on different types of ...
Zijie Li +3 more
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Plants, 2019 The emergence of multidrug resistant bacterial pathogens and the increase of antimicrobial resistance constitutes a major health challenge, leading to intense research efforts being focused on the discovery of novel antimicrobial compounds. In this study,
Phuong-Y Mai +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Frontiers in ImmunologyAngiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes have been involved in neurodegeneration, including Parkinson’s disease (PD).
Lucia Lage +6 more
doaj +1 more source
Chemical profile of Stachytarpheta schottiana by LC-HRMS/MS dereplication and molecular networking
Rodriguésia, 2021 Restingas are extreme environments present in the Atlantic Rainforest biome. These ecosystems show peculiar characteristics, like sandy soil, high salinity, and high solar exposure, which brings scientific interest to their native species. Stachytarpheta
Marcos Vinicius Toledo e Silva +6 more
doaj +1 more source
Aging cellular networks: chaperones as major participants
, 2006 We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston +56 more
core +1 more source
An algorithm for optimal network planning and frequency channel assignment in indoor WLANs [PDF]
, 2014 The increased use of wireless local area networks has led to an increased interference and a reduced performance, as a high amount of access points are often operating on the same frequency channel.
Joseph, Wout +3 more
core +1 more source